71 results about "Arbutoside" patented technology

The invention provides a stabilizer for Pickering emulsion and application of the stabilizer, and relates to the technical field of Pickering emulsion preparation. The stabilizing agent for the Pickering emulsion is obtained by compounding 6 '-O-caffeoyl arbutin and cellulose nanocrystals. In specific application, the 6'-O-caffeoyl arbutin and the cellulose nanocrystals are prepared into a water phase, and then the water phase is mixed with an oil phase to prepare the Pickering emulsion. According to the preparation method, the defects in the prior art are overcome, the stability of the Pickering emulsion is effectively improved, meanwhile, the oxidation resistance effect of the Pickering emulsion is further enhanced, and the application value of the Pickering emulsion is improved.

The invention belongs to the technical field of cosmetics, and particularly relates to whitening and freckle-removing essence oil and a preparation method thereof. According to the invention, adamantane formyl is introduced into an alpha-arbutin benzene ring to obtain the adamantane formyl modified alpha-arbutin derivative, so that the compatibility of alpha-arbutin and base oil is enhanced; the alpha-arbutin is prevented from being converted into hydroquinone by utilizing the large steric effect of adamantane formyl, so that the safety of the whitening and freckle-removing essence oil is improved; the tranexamic acid is wrapped by the ceramide nano-emulsion, so that the skin allergy risk caused by ingestion of the tranexamic acid is reduced; the ceramide nano-emulsion and tranexamic acid act together to repair skin collagenous fibers, block melanin transfer and inhibit melanin synthesis; trilinolein and glabridin are catalyzed by lipase to form a compound, so that the molecular compatibility and photo-thermal stability of glabridin are enhanced; glycerin promotes transdermal absorption of glabridin and enhances the efficacy of the whitening and freckle-removing essence oil.

The present invention relates to an anti-allergy, whitening and freckle-removing composition and a preparation method thereof. The anti-allergy, whitening and freckle-removing composition is composed of the following components in mass fractions: 0.5-2% of Kalanchoe extract, 0.5-2% of Cornus controversa Hance extract, 0.5-2% of Yucca filamentosa extract, 0.5-2% of Chrysanthemum cinerariifolium extract, 1-3% of VC ethyl ether, 0.5-5% of arbutin, 0.1-2% of 4-butylresorcinol, 1-10% of niacinamide, 3-15% of humectant, 3-15% of emollient, 0.5-2% of penetrant, and the balance being water. The anti-allergy, whitening and freckle-removing composition is added with Kalanchoe extract, Cornus controversa Hance extract, Yucca filamentosa extract and Chrysanthemum cinerariifolium extract. Through the synergistic effect of the four extracts, the anti-allergy, whitening and freckle-removing composition has little irritation while maintaining excellent whitening and freckle-removing effects.

The invention discloses a method for synthesizing alpha-arbutin through biotransformation, and belongs to the technical field of biochemistry. A gene cloning technology is utilized, sucrose phosphorylase Spase in leuconostoc mesenteroides and sucrose phosphorylase gtfa in bifidobacterium adolescentis are screened and found through a Deep Molecules and DLKcat algorithm on a Uniprot database, novopro is utilized for codon optimization, then the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa are expressed on a plasmid vector PET-28a and are converted into an escherichia coli BL21 (DE3) strain, and the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa in the bifidobacterium adolescentis are obtained. An engineering strain for heterologous expression of the gene is constructed by taking the gene as a chassis cell. According to the process, sucrose and hydroquinone are taken as co-substrates, and bioconversion is carried out under the action of sucrose phosphorylase from different sources to obtain alpha-arbutin.

The application discloses a preparation method of arbutin analogues with high transdermal absorption efficiency, and is characterized in that the method comprises the following steps: under the action of a solvent and a catalyst, compound I and compound II are subjected to esterification to obtain compound III, wherein the compound III is the arbutin analogue. The arbutin (compound I) is used as a raw material, the structure of the arbutin is modified through esterification, the transdermal performance of the arbutin is improved, the bioavailability is increased, and finally the whitening effect is improved.

This invention discloses a composition with synergistic whitening activity and its application in whitening and brightening daily chemical personal care products. β-Arbutin has a price advantage, but its whitening activity needs improvement. This invention provides a composition consisting of β-arbutin and turmeric ketone diol. In this composition, β-arbutin and turmeric ketone diol exhibit synergistic whitening activity. Combining turmeric ketone diol with β-arbutin significantly enhances the whitening activity of β-arbutin. Therefore, this composition can be used to prepare whitening and brightening daily chemical personal care products, such as facial cleansers, face creams, hand creams, lotions, and face masks.

The application discloses a mycobacterium maltose transferase Co GlgE and an encoding gene and application thereof.The maltose transferase Co The amino acid sequence of the GlgE is shown as SEQ ID NO.1.The application discloses a maltose transferase Corallococcus derived from mycobacterium sp.EGB Co GlgE, which can disperse maltoligosaccharide with a polymerization degree (DP) X into products with a DP of X ± 2n (X ≥ 3). Co The GlgE has glycosylation modification effects on alpha-arbutin and beta-arbutin, the biological activity of the modified arbutin is significantly improved, and the application value of the arbutin as an additive of whitening skin care products is improved.

The invention discloses a quantum chemical screening method for extracting arbutin, and relates to the technical field of natural product extraction, and the quantum chemical screening method comprises the following steps: constructing an arbutin single-molecule model and a hydrogen bond donor and hydrogen bond receptor single-molecule model by using GaussView software, firstly performing conformation search through MOPAC and molplus programs to obtain a most stable molecular structure, and then extracting the arbutin from the molecular structure; carrying out geometric optimization and single-point energy calculation by utilizing Gaussian; the optimized hydrogen bond donor and hydrogen bond acceptor establish random clusters according to different molar ratios, the random clusters with target molecules are established, a cluster model with an optimal structure is selected for geometric optimization and single-point energy calculation, meanwhile, the binding energy between the eutectic solvent and arbutin is calculated, and IGMH analysis, ESP analysis and AIM analysis are carried out. The invention provides a universal method for green and efficient extraction of active ingredients of natural products.

The present invention provides an α-glucosidase mutant and its application in the synthesis of α-arbutin, including the following steps: using maltose and hydroquinone as substrates, and using the recombinant bacterium as a catalyst, carrying out a catalytic reaction under heating conditions to obtain the α-arbutin. The synthesis method of the present invention uses maltose and hydroquinone as reaction substrates and uses whole-cell catalysis to generate α-arbutin; at the same time, the sequence of the α-glucosidase mutant is integrated into the pRSEDuet-1 expression vector, transferred into Escherichia coli BL21(DE3) for expression, and the reaction system of the recombinant bacterium is optimized to determine the optimal catalytic conditions. Under the optimal conditions, the yield of α-arbutin is 24.8 g / L, and the yield can reach 95.6%, which is 1.2 times higher than that of the original strain, and has good application prospects.

The invention discloses an amylosucrase mutant and application thereof in synthesis of alpha-arbutin, the mutant is obtained by mutation of an amino acid sequence of amylosucrase derived from coprophilobacterium mediterranei, and the amino acid sequence of the mutant is shown as SEQ ID NO.4. The invention further discloses a preparation method of the amylosucrase mutant. Compared with a wild strain, the catalytic activity, the temperature stability and the substrate tolerance of the amylosucrase mutant disclosed by the invention are remarkably improved; the recombinant bacteria constructed by using the recombinant bacteria can be used as a whole-cell catalyst to efficiently catalyze a substrate to synthesize alpha-arbutin in a reaction system containing hydroquinone. Therefore, the amylosucrase mutant disclosed by the invention has a good application prospect.

The invention belongs to the technical field of biology, and particularly provides an arbutin synthetase mutant and application thereof. The arbutin synthetase mutant is obtained through rational design and enzyme evolution screening on the basis of an amino acid sequence as shown in SEQ ID NO: 1, and compared with wild arbutin synthetase, the arbutin synthetase mutant is changed in protein structure and function. The catalytic activity of the arbutin synthetase mutant provided by the invention is obviously improved, and higher conversion rate and conversion rate from arbutin synthetase to beta-arbutin can be obtained. A shikimic acid pathway is enhanced in escherichia coli, and an arbutin synthetase mutant gene is introduced to construct a high-yield beta-arbutin producing strain. The method for producing beta-arbutin has the characteristics of simplicity in operation, low cost, high product synthesis efficiency and reduction of environmental pollution, and has a good industrialization prospect.

The invention relates to a difunctional gastrodia elata glycosyl transferase GaUGT015 gene and application thereof in preparation of gastrodin and arbutin, and belongs to the technical field of biology. The nucleotide sequence of the difunctional glycosyl transferase GaUGT015 gene of the gastrodia elata is shown as SEQ ID NO.1, and the total length of the sequence is 1407 bp; the amino acid sequence of the encoded protein is as shown in SEQ ID NO.2, and 469 amino acid residues are encoded. The gastrodia elata bifunctional glycosyl transferase GaUGT015 gene disclosed by the invention can be used as a biosynthesis regulation gene of gastrodin and arbutin, is applied to preparation of gastrodin and arbutin, and is remarkable in application prospect and easy to popularize and apply.

The present invention provides an enhanced whitening cosmetic composition comprising (A) concentrated birch sap and (B) one or more substances selected from arbutin, tranexamic acid, niacinamide, glabridin, ascorbic acid, ascorbyl glucoside, ascorbyl dipalmitate and ascorbyl tetraisopalmitate, wherein the concentrated birch sap is concentrated at a multiple of about 1.05-6 times, preferably about 1.1-5 times, and more preferably about 1.2-4 times.

The invention discloses a whitening and spot-fading composition based on a fermented jasmine flower extract. The whitening and spot-fading composition comprises the following components in parts by mass: 0.1-1 part of a nano emulsifier, 0.5-8 parts of the fermented jasmine flower extract, 0.5-1.5 parts of arbutin and 1-3 parts of tranexamic acid. The nano emulsifier is a mixture of hydrogenated lecithin and phytosterol, the mass fraction ratio of arbutin to tranexamic acid is 0.5: 1, and the fermented jasmine flower extract specifically comprises a jasmine flower extract, a lactobacillus fermentation extract, water, 1, 2-hexanediol and 1, 2-pentanediol. The average particle size of the emulsion is about 256.56 nm through a nano emulsification technology, and compared with a conventional system, the transdermal absorption efficiency of active ingredients such as the jasmine flower extract, arbutin and tranexamic acid can be greatly improved, so that the active ingredients can reach action targets more easily; the problem of non-uniform dispersion caused by component solubility difference can be solved, the active component analysis risk is remarkably reduced, the system stability is improved, and the whitening and spot fading effects are enhanced.

The invention discloses an amylosucrase mutant and application thereof in synthesis of alpha-arbutin, and belongs to the technical field of genetic engineering. An amylosucrase mutant is obtained through an error-prone PCR technology, the mutant is obtained by mutation on an amylosucrase amino acid sequence derived from coprophilobacterium mediterranei, and the amino acid sequence of the amylosucrase mutant is shown as SEQ ID NO.4. The invention further discloses a preparation method of the amylosucrase mutant. Compared with a wild strain, the amylosucrase mutant disclosed by the invention has higher catalytic activity, temperature stability and substrate tolerance; when the catalyst is added into a hydroquinone-containing reaction system, alpha-arbutin can be efficiently catalyzed and synthesized. Therefore, the amylosucrase mutant disclosed by the invention is suitable for industrial production and has a good application prospect.

The invention discloses construction and application of a recombinant escherichia coli engineering strain with high yield of beta-arbutin, and belongs to the technical field of gene engineering and biological engineering. According to the invention, a key gene for synthesizing beta-arbutin is regulated and expressed by adopting a temperature-sensitive promoter; an enzyme mutant aroGS180F capable of resisting feedback inhibition is introduced; an exogenous phosphoketolase pathway is introduced to enhance E4P supply; an acetic acid branch pathway gene is knocked out, so that the formation of a by-product acetic acid is reduced, and the yield of beta-arbutin of the constructed engineering strain can reach 6.83 g / L. The high-yield beta-arbutin escherichia coli recombinant strain constructed by the invention lays a foundation for the subsequent biosynthesis of beta-arbutin and derivatives, and has potential value and significance for the development of synthetic biology.

The invention relates to the technical field of cosmetic component detection and analysis, and discloses a method for rapidly recognizing arbutin in cosmetics based on surface enhanced Raman spectroscopy, AgNPs sol is prepared by an ascorbic acid oxidation-reduction method, and an SERS sensing interface is constructed through aspartic acid electro-polymerization modification; for different dosage forms of cosmetics, a to-be-detected solution is obtained through methanol extraction and centrifugal filtration purification, the to-be-detected solution and AgNPs sol are mixed and adsorbed, then a Raman spectrum is collected, pretreatment is conducted through combination of multivariate scatter correction and standard orthogonal transformation, characteristic wavelengths are screened through a genetic algorithm-combined interval partial least square method, and detection is achieved through combination of qualitative and quantitative models. Through cooperation of sensing interface specific modification and a data processing technology, the arbutin signal recognition capability is enhanced, matrix interference is eliminated, rapid and accurate detection of arbutin in cosmetics is realized, and the effects of high sensitivity, high specificity and simple and convenient operation are achieved.

The present invention discloses a whitening composition with synergistic effect of short peptide and arbutin and its application. The whitening composition with synergistic effect of short peptide and arbutin comprises arbutin and a short peptide; the short peptide is selected from one or more of AHW, LRY, LWF, CFV and IWC. The whitening composition with synergistic effect of short peptide and arbutin of the present invention produces a synergistic effect by combining a specific short peptide with arbutin, synergistically increasing the inhibitory effect on tyrosinase, so that arbutin can achieve a better tyrosinase inhibition effect at a lower, safer and more stable concentration, and can greatly reduce the use concentration of arbutin, reduce cytotoxicity and improve stability. The whitening composition of the invention has the advantages of low concentration, high efficiency, low toxicity and good stability, and has good application prospects.

The invention discloses medical silicone gel for scar repair and a preparation method and application thereof, and relates to the technical field of medical gel. The aloe polysaccharide silicone gel mask comprises the following raw materials in percentage by mass: 25-45% of aloe polysaccharide silicone gel, 1-2% of sodium hyaluronate, 0.2-0.8% of poly-L-lactic acid, 2-4% of vitamin E, 5-8% of asiaticoside, 1-3% of resveratrol, 1-2% of curcumin, 1-2% of hydroquinone, 2-4% of arbutin, 2-4% of a vitamin C derivative, 3-5% of a traditional Chinese medicine composition, 0.5-1.5% of an odor regulator, 0.1-0.3% of a preservative and the balance of water. And the balance of purified water. The smell regulator is a pH response release type adsorbent. The medical silicone gel not only can effectively repair scars, but also is good in skin feeling and not prone to sensitivity.

The application discloses a preparation method and application of a nano self-assembly composition of arbutin-berberine, and comprises the following steps: dissolving berberine in methanol at 38-42 DEG C, adding an arbutin super-pure water solution at 38-42 DEG C, and stirring and keeping warm for 0.8-1.2 h to obtain a self-assembly solution; then, the self-assembly solution is subjected to vacuum rotary evaporation and freeze drying in sequence, and the nano self-assembly composition of arbutin-berberine is obtained. The traditional Chinese medicine nano self-assembly system based on arbutin and berberine is successfully constructed, the nanoparticles are spontaneously formed under mild conditions through intermolecular non-covalent interaction, the preparation process is simple and convenient, the conditions are mild, the damage of high temperature and other harsh conditions to active ingredients is effectively avoided, and the process adaptability is high.

A whitening nanocomposition, a preparation method therefor, and use thereof. The whitening nanocomposition comprises an active ingredient and a nanocarrier. The active ingredient is coated and / or adsorbed by the nanocarrier. The active ingredient comprises the following components: 1-15 parts by weight of α-arbutin, 1-15 parts by weight of nicotinamide, 1-10 parts by weight of 3-o-ethyl ascorbic acid, 0.1-1 part by weight of a Centalla asiatica extract, and 1-5 parts by weight of retinyl palmitate. The nanocarrier comprises the following components: 5-10 parts by weight of an emulsifier, 5-20 parts by weight of a polyol, 0.1-5 parts by weight of a phospholipid, and 40-60 parts by weight of water. The whitening nanocomposition has good skin permeability and retention performance and enables high-concentration enrichment, prolonged retention, and sustained release or controlled release within a target tissue, so as to be effectively taken in by target cells, thereby improving bioavailability and enhancing the whitening effect.

The invention relates to the technical field of cosmetics, in particular to a nano-coated alpha-arbutin deep eutectic and a preparation method and application thereof. The nano-coated alpha-arbutin deep eutectic is prepared from the following raw materials in parts by weight: 15 to 30 parts of soybean phospholipid, 4 to 10 parts of cholesterol, 1 to 5 parts of DSPE-PEG2000, 80 to 120 parts of choline chloride / alpha-arbutin DEA, 3 to 8 parts of trehalose and 3 to 8 parts of propylene glycol. Wherein choline chloride / alpha-arbutin DEA and alpha-arbutin form a stable deep eutectic through a hydrogen bond network by taking choline chloride as a hydrogen bond receptor, so that the problems of water solubility and photo-thermal instability of the deep eutectic are solved, and the transdermal permeation efficiency and the oxidation resistance are improved. Choline chloride / alpha-arbutin DEA is wrapped by nano-liposomes to form a physical barrier, so that external ultraviolet and high-temperature environments are avoided, the risk that the choline chloride / alpha-arbutin DEA is decomposed into hydroquinone is reduced, and the storage stability of active ingredients is prolonged.

The invention relates to application of 6 '-O-caffeoyl arbutin in preparation of a medicine for treating dementia, and belongs to the technical field of biological medicine. The 6 '-O-caffeoyl arbutin disclosed by the invention has a remarkable dementia treatment value, the action mechanism accurately fits the core pathological process of dementia, a neuroprotective effect is played by relieving oxidative stress and inhibiting inflammatory reaction, oxidative stress related indexes such as superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) can be effectively adjusted, and the dementia treatment effect is improved. The release of lactic dehydrogenase (LDH) and malondialdehyde (MDA) and the level of damage-induced nitric oxide synthase (I NOS) are reduced, so that the NMDA-induced PC12 cell damage is protected.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

The invention discloses an arbutin derivative 6-O-Caffeoylbutin as well as a preparation method and application of the arbutin derivative 6-O-Caffeoylbutin. The structural formula of a 6-O-Caffeoylbutin compound is as shown in formula (I). The invention also discloses the application of the arbutin derivative (6-O-Caffeoylbutin) disclosed by the invention in preparation of an antioxidant preparation. According to the invention, the 6-O-Caffeoylbutin extracted for the first time shows excellent antioxidant activity, the ABTB free radical scavenging capacity of the 6-O-Caffeoylbutin is higher than that of ascorbic acid and beta-arbutin, and a material basis is provided for developing novel antioxidants.

The invention discloses an amylosucrase mutant and application thereof in synthesis of alpha-arbutin, and belongs to the technical field of genetic engineering. An amylosucrase mutant is obtained through an error-prone PCR technology, the mutant is obtained by mutation on an amylosucrase amino acid sequence derived from coprophilobacterium mediterranei, and the amino acid sequence of the amylosucrase mutant is shown as SEQ ID NO.4. The invention further discloses a preparation method of the amylosucrase mutant. The amylosucrase mutant can be used for synthesis and preparation of alpha-arbutin, the amylosucrase mutant is used as a biocatalyst to convert substrate hydroquinone to generate alpha-arbutin, and the reaction conversion rate of the reaction is proved to be high. Compared with a wild type enzyme, the amylosucrase mutant constructed by the invention has the advantages that the catalytic activity, the temperature stability and the substrate tolerance are obviously improved, the production cost is reduced, and the industrial application value of the amylosucrase is effectively improved.

This invention belongs to the field of biochemical technology, specifically disclosing a 6′- O A whole-cell biosynthesis method for caffeoyl arbutin and its analogues includes the following steps: using aromatic carboxylic acids and vinyl acetates as substrates, performing a transvinylation reaction under palladium catalyst and base conditions to prepare aromatic vinyl esters; using the prepared aromatic vinyl esters as acyl donors, ... β Arbutin, using acyl acceptors, undergoes an aromatic acylation reaction in an organic solvent with whole cells of Aspergillus oryzae as a catalyst to yield the 6′- O Caffeoyl arbutin or its analogues. This invention develops a two-step whole-cell catalytic method for the efficient and sustainable synthesis of CA and its analogues. The synthesized compounds exhibit potent inhibitory activity against mushroom tyrosinase. This invention pioneers a novel green biosynthetic pathway for tyrosinase inhibitors, demonstrating significant application potential in the food preservation and cosmetics industries.

The invention discloses a whitening composition based on arbutin and nicotinamide and a preparation method thereof, and belongs to the technical field of cosmetics, the preparation method comprises the following steps: dispersing sodium alginate in hot water under high-temperature shearing, and hydrating to obtain a glue solution A; dissolving nicotinamide, alpha-arbutin, inositol and caprylyl glycol in dipropylene glycol to obtain a solution B; performing dry mixing on beta-1, 3-glucan and sodium polyglutamate, and performing high-speed shearing in hot water to obtain slurry C; cooling the slurry C, mixing with the solution B, and adding the glue solution A; and finally, standing and aging the system at 4 DEG C, spraying a trace calcium chloride ethanol solution for several times to induce the formation of a gel network, and adjusting the pH value. The technical problems that alpha-arbutin is easy to hydrolyze and inactivate and nicotinamide is high in irritation are successfully solved through a unique low-temperature ionic cross-linking gel process, the obtained product is excellent in stability, has a slow-release synergistic effect, can achieve a mild and efficient whitening effect without adding a chemical penetration enhancer, and can be applied to skin care products such as essence and ampoules.

The invention discloses an arbutin analogue, a preparation method thereof and application of the arbutin analogue in preparation of a medicine for treating chronic colitis, and belongs to the technical field of medicines. The arbutin analogue is structurally characterized in that a galactosyl group is connected with a polysubstituted benzene ring through a flexible connecting chain-(CH) n-O-to form a novel structure which is remarkably different from a known compound arbutin. The arbutin analogue is prepared through chemical synthesis, and a pharmaceutical composition containing the arbutin analogue is provided. Pharmacological experiments prove that the representative compounds hydroquinone monogalactoside and 3, 4-dihydroxyphenol galactoside show disease treatment activity obviously superior to that of arbutin in a DSS-induced mouse chronic colitis model, the disease activity index can be effectively improved, and colon tissue damage can be relieved. Therefore, the compound provided by the invention can be used for preparing medicines for preventing and / or treating chronic colitis. Formula (1)

The invention discloses a natural antibacterial agent arbutin energized self-polishing antifouling nano composite coating and a preparation method thereof.The preparation method comprises the steps that firstly, aminopropyl terminated polydimethylsiloxane and hexamethylene diisocyanate are synthesized into a prepolymer NPDI, then the prepolymer NPDI reacts with hydroxyethyl acrylate, and an organic matrix NPDA is obtained; the preparation method comprises the following steps: adsorbing arbutin by ZIF-8 to prepare ZIF-8 / Arb powder, blending the ZIF-8 / Arb powder with SiO2, adding NPDA, adding a fluorosilicone coupling agent, carrying out a blending reaction, and carrying out spraying and room temperature drying to prepare the self-polishing antifouling nano composite coating. The base body adopted by the coating is excellent in mechanical property and outstanding in structural stability, the lap joint shear strength reaches 14.08 MPa, the coating has the hydrolysis and low surface energy characteristics, and surface self-polishing and attached organism nondestructive stripping can be achieved under water flow shearing; the nano SiO2 improves wear resistance and durability, the ZIF-8 / Arb releases arbutin and Zn < 2 + > in a targeted manner in a subacid environment, synergistically and efficiently inhibits bacteria, inhibits biofilm formation, realizes long-acting active antifouling, and is suitable for a harsh marine environment.