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Substance of poly pentenol capsule and its prepn. method

A polyprenol and content technology, which is applied in the directions of capsule delivery, drug combination, and pharmaceutical formulations, can solve the problems of inability to prepare in large quantities, large loss of elution solvent, and difficulty in regenerating silica gel. Purity, the effect of overcoming large losses

Inactive Publication Date: 2005-06-15
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To prepare more than 95wt% of polyprenol actives for the development of medicines and health-care functional foods, silica gel or alumina column chromatography must be used. Not only the loss of the elution solvent is large, the separation cost is high, and the regeneration of silica gel is difficult, so it cannot batch preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]Embodiment 1 A polyprenol capsule content, including 1wt%-20wt% oil containing 70wt%-95wt% polyprenol and 20wt%-95wt% vegetable oil, containing 70wt% in this example The mass percentage of the oily substance of ~95wt% polypentenol can be 1%, 3%, 6.5%, 8%, 11%, 12.5%, 15.5%, 17, 19%, 70wt%~95wt% polypentenol The oily matter of enol can be derived from the product refined by molecular distillation technology, and can also be derived from the product refined by other methods such as column chromatography, and the mass percentage of vegetable oil can be 25%, 32%, 46%, 65%, 74%, 85%, 92%, vegetable oil can be a kind of in medicinal or edible soybean oil, olive oil, perilla oil, peanut oil, sesame oil, in the present embodiment, also can comprise the lecithin of 1%-78%, can 3%, 15%, 32%, 54%, 65%, 71%, 75%, can also include 0.1-2% vitamin E, can be selected as 0.3, 0.5%, 0.9%, 1.2%, 1.4% , 1.7%, 1.9%.

Embodiment 2

[0022] Example 2 Take 70g of 70%-95% polyprenyl alcohol oil, 920g of soybean oil, and 10g of vitamin E, put them into a glass and stir evenly, add edible gelatin, glycerin and water into the sol pot in proportion, Heat and stir at -85°C for 30min-60min, then vacuumize to remove air bubbles in the glue. Then make the soft capsule content and glue in the pill press machine to make capsules, and then dry them in the setting machine at 10°C and then sort the pills and pack them. The weight of each capsule is 250mg-1000mg, preferably 250mg. The capsules contain 1-50 mg of polyprenol.

Embodiment 3

[0023] Example 3 Take 50g of 70%-95% polyprenol oil, 300g of soybean oil, 650g of lecithin, and 20g of vitamin E, put them into a glass and stir them uniformly. Add edible gelatin, glycerin and water into the sol pot in proportion, heat and stir at 75-85°C for 30min-60min, and then vacuumize to remove the air bubbles in the glue solution. Then the contents and glue of the prepared soft capsules are made into capsules in a pill pressing machine, and then dried at 10°C in a setting machine for sorting and packaging. The content of each capsule weighs 250mg-1000mg, preferably 500mg, and each capsule contains 1-50mg of polyprenol.

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Abstract

A polypentenol capsule containing oil polypentenol (1-20 wt.%) and plant oil (20-95 wt.%). It is prepared from the ointment containing polypentanol through vacuum molecular distilling, vacuum molecular distilling of the residue to obtain oily polypentenol, and proportionally mixing it with plant oil.

Description

technical field [0001] The invention relates to a medicine capsule content and a preparation method thereof, in particular to a polyprenol capsule content and a preparation method thereof. Background technique [0002] Latvia and Russia reported the separation and preparation of polyprenol from European scotch pine, spruce and other needles (RU2,053,992 and GB2,310,138), and developed a polyprenol preparation "ROPREN" for immune function regulation. Russian patent RU2005475 also reported the synthesis of polyprenyl phosphate by Siberian spruce coniferous polyprenol for the preparation of antiviral drugs. Approved by the Ministry of Health of Latvia to conduct Phase II and Phase III clinical trials of hepatitis C virus. In addition, the Ministry of Health of Latvia has approved the marketing of polyprenol as a food and cosmetic additive. The Institute of Epidemiology of the Russian Academy of Medical Sciences has conducted in-depth research on the an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/765A61P1/16A61P31/12A61P35/00
Inventor 王成章沈兆邦刘妤婵
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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