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Compound medicine compatibility method of ion pair agent and vanadium compound and the application thereof

An ion-pairing reagent, vanadium compound technology, applied in the direction of heavy metal compound active ingredients, anhydride/acid/halide active ingredients, medical preparations containing active ingredients, etc., can solve problems such as low bioavailability

Inactive Publication Date: 2005-06-29
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, the main problems of the clinical application of insulin-like vanadium compounds are: (1) low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Compatibility method one includes the following substances:

[0023] Vanadyl(IV) sulfate 0.20g

[0024] Salicylic acid 0.15g

[0025] Aspirin 0.50g

[0026] Sodium acetate 1.5g

[0027] Distilled water 1000ml

[0028] Dissolve salicylic acid and aspirin in water, add vanadyl sulfate, mix and stir until completely dissolved, add sodium acetate in 3 times to dissolve, filter with a 0.5 μm filter membrane, and put it into a packaging bottle.

[0029] This method can be used to produce vanadium mineralized water that can provide highly bioactive vanadium trace elements, lower blood sugar and prevent cardiovascular complications of diabetes.

Embodiment 2

[0030] Embodiment 2: the compound compatibility method two of ion-pair reagent and vanadium compound

[0031] Compatibility method 2 includes the following substances:

[0032] Vanadyl(IV) citrate 10g

[0033] Weichangning 150g

[0034] Appropriate amount of starch slurry (17%)

[0035] Talc powder 15g

[0036] Starch 266g

[0037] Light liquid paraffin 0.25g

[0038] Grind and mix vanadyl citrate (IV) and Weichangning, pass through a 100-mesh sieve and mix with about 1 / 3 starch, add starch slurry to make a soft material, pass through a 14-mesh sieve to granulate, wet granules at 70°C Dry, and pass through a 12-mesh sieve for granulation. Add the remaining starch (pre-dried at 100°C to 105°C) and talcum powder adsorbed with liquid paraffin (spray light liquid paraffin into the talcum powder and mix well), and mix evenly. piece.

[0039] The method is used to prepare a tablet that can provide vanadium trace elements with high bioactivity, and has the effects of lowering...

Embodiment 3

[0040] Embodiment 3: the compound recipe compatibility method three of ion-pair reagent and vanadium compound

[0041] Compatibility method three includes the following substances:

[0042] Vanadyl(IV) acetylacetonate complex 20g

[0043] Ginkgo biloba total flavonoids extract 200g

[0044] Starch 250g

[0045] Mix the total flavonoids extract of Ginkgo biloba leaves with starch, dry, grind, and pass through a No. 7 sieve. The vanadyl (IV) complex of acetylacetonate is ground and passed through a No. 7 sieve. Mix the above products thoroughly, and after passing the inspection, put them into capsules.

[0046] The method can be used to prepare 100 capsules, which can provide vanadium trace elements with high biological activity, and has the effects of lowering blood sugar and preventing cardiovascular complications of diabetes at the same time.

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PUM

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Abstract

The invention discloses a compound medicine compatibility method of ion pair agent and vanadium compound and the application, wherein the compatibility method comprises, matching vanadium compound with ion reagent with no strong coordination capacity by the mol ratio of 1:1-1:10, when the aqueous solution of vanadium compound is cation, then anion reagent is selected as the ion pair reagent, when the aqueous solution of the vanadium compound is anion, then cationic reagent is selected as the ion pair reagent, the method can be applied for preparing various medicaments for treating and preventing diabetes.

Description

technical field [0001] The invention relates to a compound compatibility method of an ion-pair reagent and a vanadium compound and its application. Background technique [0002] Diabetes mellitus is a common metabolic disease with a high incidence in middle-aged and elderly people. In recent years, the incidence rate among the urban population in my country, especially among young people, has shown an increasing trend. Insulin insufficiency and / or resistance is the cause of diabetes, but the pathological mechanism is not clear. Therefore, at present, there is a lack of effective therapeutic drugs for diabetic patients, especially type II insulin-resistant patients. [0003] Vanadium is an essential trace element for the human body. A large number of in-depth studies and investigations have shown that various types of vanadium compounds have a significant effect of lowering blood sugar (Yang Xiaogai, Yang Xiaoda, Wang Kui, The chemical basis and medicinal prospects of the ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/16A61K9/20A61K9/46A61K9/48A61K31/19A61K31/28A61K31/4415A61K33/24A61P3/10
Inventor 张悦杨晓达
Owner PEKING UNIV
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