The invention relates to a traditional Chinese medicine antibiotic skincare hand cleanser prepared from mixed materials of a traditional Chinese medicine extract, a surfactant, an antiseptic, glycerin, an essence and water. The traditional Chinese medicine extract is prepared from raw materials of, by weight: 35-45 parts of lightyellow sophora root, 15-25 parts of amur corktree bark, 15-25 parts of Chinese gentian, 5-15 parts of common cnidium fruit, and 5-15 parts of belvedere fruit. The raw materials are extracted by using water, and the density d of the obtained traditional Chinese medicine extract is 1.5-1.8g/ml. The traditional Chinese medicine antibiotic skincare hand cleanser provided by the invention has certain inhibitive effects against escherichia coli, staphylococcus aureus, and candida albicans, and provides certain preventive effects against eczema, skin pruritus, and the like. The hand cleanser is also advantaged in small dosage, high decontamination capability, good sterilization effect, and low irritation. The hands are delicate and not dry after washing. According to the invention, the formula of the hand cleanser is simple. With the hand cleanser, modern market requirements on naturalness, environment-friendliness, and high antibiotic efficiency can be satisfied.