Medicine for treating tumor

A technology for tumor diseases and arsenic trioxide, which is applied in the field of drug compositions for the treatment of tumor diseases, can solve problems such as impact and patients' intolerance of treatment, and achieve the effect of improving the treatment effect and reducing side effects

Inactive Publication Date: 2005-07-06
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has been found that the impact of conventional doses of arsenic trioxide on cardiac function often leads to patients being unable to tolerate arsenic trioxide and having to discontinue treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0026] Embodiment 1: This embodiment is made of arsenic trioxide and verapamil, and the weight ratio of arsenic trioxide to verapamil is 5:1-2:1. The production method of this embodiment is: take commercially available analytically pure arsenic trioxide, sublimate it at 180-250°C, collect the sublimated product, dissolve it with 5 molar NaOH solution, and then adjust the pH value to 8-8.5 with 1 molar hydrochloric acid Concentrate with a vacuum pump, mix with 1mol / L sodium hydroxide solution after concentration to make a solution, add verapamil into the solution of arsenic trioxide according to the weight ratio and mix evenly.

specific Embodiment approach 2

[0027] Embodiment 2: This embodiment is made of arsenic trioxide and verapamil, and the weight ratio of arsenic trioxide to verapamil is 5:1.

specific Embodiment approach 3

[0028] Embodiment 3: This embodiment is made of arsenic trioxide and verapamil, and the weight ratio of arsenic trioxide to verapamil is 4:1.

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PUM

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Abstract

Disclosed is a medicine for treating tumor which is a composition prepared from arsenic trioxide and verapamil by the weight ratio of 5 : 1-2 :1 wherein the verapamil has inhibitory action to both activated and deactivated L-type calcium passages, the effect for the treatment can be improved.

Description

Technical field: [0001] The invention relates to a composition of drugs for treating tumor diseases. It specifically relates to a combination preparation of arsenic trioxide and verapamil. Background technique: [0002] Arsenic is a non-metallic element widely distributed in nature. Arsenic occurs naturally in the form of compounds. Common arsenic compounds are arsenic trioxide (As 2 o 3 , commonly known as arsenic), realgar (As 2 S 2 ), orpiment (As 2 S 3 )Wait. As early as 2,400 years ago, people in the East and West began to use arsenic to treat everything from syphilis to cancer. For example, in the Western Han Dynasty in the 2nd century BC, arsenic began to be used as a raw material for alchemy. Tao Hongjing first recorded in "Shen Nong's Materia Medica" written in the 5th century AD: "Eating realgar can lighten one's life and become a fairy." Li Shizhen in Ming Dynasty described in detail the various medicinal uses of arsenic in "Compendium of Materia Medica"...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/36A61P35/00
Inventor 杨宝峰艾静崔浩
Owner HARBIN MEDICAL UNIVERSITY
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