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Drop pills containing bear gall and tendril-leaved fritillary bulb and preparation method thereof

A technology of bear bile and bear bile powder, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve problems such as long dissolution time, low dissolution rate, and inaccurate dosage, so as to avoid gastric Effects of intestinal irritation symptoms, accelerated dissolution and absorption, and improved bioavailability

Inactive Publication Date: 2005-07-06
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
However, syrup preparations also have the disadvantages of low drug content, large doses, inaccurate doses, inconvenient taking, and inconvenient carrying.
[0013] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also give some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] Now with several groups of specific examples, the preparation method of Xiongdan Chuanbei dripping pills of the present invention will be further described.

[0037] Group 1: Tests with a single matrix

[0038] 1. According to the section [Preparation method of a kind of medicinal extract], the extract dry powder containing 4 kinds of pure Chinese medicine active ingredients such as bear bile powder, Chuan Fritillaria, almond water, and menthol was prepared for use;

[0039] 2. Substrate: polyethylene glycol (2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0040]3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0041] 4. Follow the [Preparation Method] to prepare Xiongdan Chuanbei Dropping Pills of various specifications.

[0042] [test results]

[0043...

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PUM

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Abstract

Disclosed is a bear gall and tendril-leaved fritillary bulb dripping pill, which is a pharmaceutical composition having the functions of heat-clearing and phlegm resolving and cough-relieving, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, higher medicinal content, smaller amount of administration, accurate administration dosage, easy administering, low price, and facilitated carrying. The medicine is prepared through the conventional drop pill preparing process.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has heat-clearing and phlegm-relieving and cough-relieving effects, and is used for treating symptoms such as phlegm-heat cough, coughing up phlegm, phlegm filled with shortness of breath, and unpleasant phlegm, especially based on Xiongdan Chuanbei Oral Liquid , a pharmaceutical composition oral drop pill preparation reformed from the dosage form. Background technique [0002] According to the formula and extraction process given in the national drug standard WS-11130 (ZD-1130)-2002, Xiongdan Chuanbei Oral Liquid is a kind of oral liquid with heat-clearing, phlegm-relieving and cough-relieving effects, which is used to treat phlegm-heat cough , Coughing up phlegm, shortness of breath, full of phlegm, and unpleasant phlegm and other symptoms of pure Chinese medicine preparations, which have been clinically verified to have stable quality and definite curative effect. [0003] The fol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K35/413A61P11/10A61P11/14
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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