Reagent kit for forecasting susceptibility of intolerance type dementia preaecox and primer used thereby

A schizophrenia, susceptibility technology, applied in the field of guidance for prevention and treatment, kits and primers for predicting susceptibility to paranoid schizophrenia

Inactive Publication Date: 2005-07-06
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few successful reports on the determination of susceptibility genes for polygenic diseases by simply using positional cloning strategies. At present, there is another method for the study of susceptibility genes for polygenic diseases—the candidate gene method, that is, to directly study the candidate genes of the disease. The relationship between variants and disease, mainly based on case-control association analysis

Method used

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  • Reagent kit for forecasting susceptibility of intolerance type dementia preaecox and primer used thereby
  • Reagent kit for forecasting susceptibility of intolerance type dementia preaecox and primer used thereby
  • Reagent kit for forecasting susceptibility of intolerance type dementia preaecox and primer used thereby

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Example 1 Sample collection of sporadic cases of paranoid schizophrenia

[0089] In view of the complexity of the clinical classification of schizophrenia, its own heterogeneity and the overlap with related diseases may interfere with the final analysis results, the inventors only selected paranoid schizophrenia as the research object, and after enrollment Strict inclusion and exclusion criteria were used to ensure the relative specificity of the included samples.

[0090] All the cases were collected from inpatients of northern Han nationality who were hospitalized in the Institute of Mental Health of Peking University between March 2000 and March 2001. Semi-quantitative psychiatric examinations were performed on patients using the Neuropsychiatric Clinical Assessment Form (SCAN), and all examinations were completed by inventors trained by SCAN (refer to the requirements in the SCAN examination manual and instruction manual for specific operations), and the matching CA...

Embodiment 2

[0108] Example 2 Collection of a nuclear family with paranoid schizophrenia

[0109] A nuclear pedigree (Trios) consisting of paranoid schizophrenic patients and their healthy parents was collected from the Han population in northern China. All patients were admitted to the hospital between 2000 and 2002, and the diagnostic and exclusion criteria were the same as those of the above-mentioned sporadic cases. A total of 95 families meeting the criteria were collected. Peripheral blood samples from each member of all families were collected for use.

[0110] Before collecting sporadic cases and family pedigrees, ensure that all members understand the purpose of blood collection, that is, they have the right to know. After the blood sample provider understands all the situation and agrees, and signs the "Informed Consent Form", blood sampling and other Situation investigation.

Embodiment 3

[0111] Example 3 Collection of Healthy Control Samples

[0112] All samples were from hospital staff and healthy blood donors, requiring good health, no serious physical diseases, no family history of genetic diseases, no current and past mental illnesses and family history of mental illnesses, no history of drug abuse. After asking for my consent and signing the "Informed Consent Form", peripheral blood samples were collected for future use.

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Abstract

The invention relates to kits for predicting paranoid schizophrenia susceptibility and primers therefor. More particularly, the invention relates to kits and primers for predicting paranoid schizophrenia susceptibility which designed by utilizing six single nucleotide polymorphism (SNP) site combinations of the paranoid schizophrenia susceptible genes COMT, ALDH, ADH and MAO. The invention also relates to applications of the COMT, ALDH, ADH and MAO genes for preparing diagnostic agents for predicting paranoid schizophrenia susceptibility.

Description

technical field [0001] The invention relates to a kit for predicting susceptibility to paranoid schizophrenia and primers used. More specifically, the present invention relates to a reagent designed to predict the susceptibility of paranoid schizophrenia by utilizing six single nucleotide polymorphism (SNP) site combinations of schizophrenia susceptibility genes COMT, ALDH3B1, ADH1B and MAOA Cassettes and primers. The invention also relates to the application of the four genes COMT, ALDH3B1, ADH1B and MAOA in the preparation of a diagnostic agent for predicting the susceptibility of paranoid schizophrenia, and its guiding role in the prevention and treatment of paranoid schizophrenia. Background technique [0002] Schizophrenia is one of the most serious mental illnesses with a lifetime prevalence of up to 1%. Such a large group of patients not only brings a heavy economic burden to families and society, but also seriously threatens social security and stability. Therefor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 许琪沈岩计宏凯季梁原岩波沈渔邨
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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