Reagent kit for forecasting susceptibility of intolerance type dementia preaecox and primer used thereby
A schizophrenia, susceptibility technology, applied in the field of guidance for prevention and treatment, kits and primers for predicting susceptibility to paranoid schizophrenia
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Examples
Embodiment 1
[0088] Example 1 Sample collection of sporadic cases of paranoid schizophrenia
[0089] In view of the complexity of the clinical classification of schizophrenia, its own heterogeneity and the overlap with related diseases may interfere with the final analysis results, the inventors only selected paranoid schizophrenia as the research object, and after enrollment Strict inclusion and exclusion criteria were used to ensure the relative specificity of the included samples.
[0090] All the cases were collected from inpatients of northern Han nationality who were hospitalized in the Institute of Mental Health of Peking University between March 2000 and March 2001. Semi-quantitative psychiatric examinations were performed on patients using the Neuropsychiatric Clinical Assessment Form (SCAN), and all examinations were completed by inventors trained by SCAN (refer to the requirements in the SCAN examination manual and instruction manual for specific operations), and the matching CA...
Embodiment 2
[0108] Example 2 Collection of a nuclear family with paranoid schizophrenia
[0109] A nuclear pedigree (Trios) consisting of paranoid schizophrenic patients and their healthy parents was collected from the Han population in northern China. All patients were admitted to the hospital between 2000 and 2002, and the diagnostic and exclusion criteria were the same as those of the above-mentioned sporadic cases. A total of 95 families meeting the criteria were collected. Peripheral blood samples from each member of all families were collected for use.
[0110] Before collecting sporadic cases and family pedigrees, ensure that all members understand the purpose of blood collection, that is, they have the right to know. After the blood sample provider understands all the situation and agrees, and signs the "Informed Consent Form", blood sampling and other Situation investigation.
Embodiment 3
[0111] Example 3 Collection of Healthy Control Samples
[0112] All samples were from hospital staff and healthy blood donors, requiring good health, no serious physical diseases, no family history of genetic diseases, no current and past mental illnesses and family history of mental illnesses, no history of drug abuse. After asking for my consent and signing the "Informed Consent Form", peripheral blood samples were collected for future use.
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Description
Claims
Application Information
- IPC
- C12Q1/68
- Inventors
- 许琪; 沈岩