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Methods and apparatus for extrusion of vesicles at high pressure

A vesicle, high-pressure technology, applied in pharmaceutical formulations, microcapsule preparations, medical preparations of inactive ingredients, etc., can solve the possibility of difficult lipid extrusion, low flow rate, increased production time and cost pollution, etc. question

Inactive Publication Date: 2005-07-06
ESPERION THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lipids may also be difficult to extrude due to impurities in the starting material, such as by-product resin contamination from the manufacturing process
Difficult-to-extrude lipids also have lower flow rates and are therefore more likely to foul and clog membranes than other lipids
As explained above, clogged or fouled membranes must be cleaned and replaced, adding time and cost to production and the possibility of fouling

Method used

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  • Methods and apparatus for extrusion of vesicles at high pressure
  • Methods and apparatus for extrusion of vesicles at high pressure
  • Methods and apparatus for extrusion of vesicles at high pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0100] 1. Extrude 20% POPC through a 0.1 μm polycarbonate track-etched membrane at 600 psi

[0101] The following examples demonstrate that, using conventional methods and apparatus, difficult-to-extrude lipids can clog or foul extruded membranes if cleaning agents are not advantageously used.

[0102] In a 50 ml conical tube, add 2 g of 1-palmitoyl-2-oleoyl-sn-propanetrioxy-3-phosphocholine (POPC) (Genzyme, Cambridge MA, cat. no. LP-04-031) Add 8 ml of phosphate-buffered saline solution (PBS) (140 mM saline, 20 mM phosphate, pH=7.4), and shake vigorously by hand for about 5 minutes to form a uniform suspension of 200 mg / ml POPC MLVs in PBS. Follow the extruder manufacturer's instructions in 10 ml of LIPEX TM 2-stacked 0.1 μm polycarbonate track-etched membrane (PCTE) NUCLEPORE mounted on an extruder (Northern Lipids, Vancouver, British Columbia, Canada) TM membrane (Whatman, Ann Arbor, MI; catalog: 110605) and rinsed with PBS. The POPC-PBS MLV suspension was passed through...

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Abstract

The present invention relates generally to methods and devices for the preparation of vesicles, including micelles, particularly liposomes, the method comprising extruding a solution containing a substance capable of forming vesicles through a mesh membrane under high pressure.

Description

[0001] This application claims the benefit of Provisional Application No. 60 / 326,032, filed September 28, 2001, under 35 U.S.C. §119, the entire contents of which are hereby incorporated by reference. field of invention [0002] The present invention relates generally to methods and methods for the preparation of vesicles, including micelles, especially liposomes, by extruding a solution containing material capable of forming vesicles through screen membranes under high pressure device. Background technique [0003] The use of liposomes for drug delivery has been proposed for a variety of drugs, especially those administered parenterally. Liposomes have the potential to provide controlled-release "dockets" of administered drugs over an extended period of time and have the potential to reduce drug side effects by limiting the concentration of free drug in the blood. Liposomes can also alter the tissue distribution and absorption of drugs in a therapeutically favorable manner...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/10A61K47/14B01J13/02B01J13/04
CPCA61K9/1277B01J13/04A61K9/127
Inventor K·R·希尔W·罗德里格扎G·A·西
Owner ESPERION THERAPEUTICS
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