Methods and apparatus for extrusion of vesicles at high pressure

A vesicle, high-pressure technology, applied in pharmaceutical formulations, microcapsule preparations, medical preparations of inactive ingredients, etc., can solve the possibility of difficult lipid extrusion, low flow rate, increased production time and cost pollution, etc. question

Inactive Publication Date: 2005-07-06
ESPERION THERAPEUTICS
View PDF29 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lipids may also be difficult to extrude due to impurities in the starting material, such as by-product resin contamination from the manufacturing process
Difficult-to-extrude lipids also have lower flow rates and are therefore more likely to foul and clog membranes than other lipids
As explained above, clogged or fouled membranes must be cleaned and replaced, adding time and cost to production and the possibility of fouling

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods and apparatus for extrusion of vesicles at high pressure
  • Methods and apparatus for extrusion of vesicles at high pressure
  • Methods and apparatus for extrusion of vesicles at high pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0100] 1. Extrude 20% POPC through a 0.1 μm polycarbonate track-etched membrane at 600 psi

[0101] The following examples demonstrate that, using conventional methods and apparatus, difficult-to-extrude lipids can clog or foul extruded membranes if cleaning agents are not advantageously used.

[0102] In a 50 ml conical tube, add 2 g of 1-palmitoyl-2-oleoyl-sn-propanetrioxy-3-phosphocholine (POPC) (Genzyme, Cambridge MA, cat. no. LP-04-031) Add 8 ml of phosphate-buffered saline solution (PBS) (140 mM saline, 20 mM phosphate, pH=7.4), and shake vigorously by hand for about 5 minutes to form a uniform suspension of 200 mg / ml POPC MLVs in PBS. Follow the extruder manufacturer's instructions in 10 ml of LIPEX TM 2-stacked 0.1 μm polycarbonate track-etched membrane (PCTE) NUCLEPORE mounted on an extruder (Northern Lipids, Vancouver, British Columbia, Canada) TM membrane (Whatman, Ann Arbor, MI; catalog: 110605) and rinsed with PBS. The POPC-PBS MLV suspension was passed through...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
water contact angleaaaaaaaaaa
water contact angleaaaaaaaaaa
water contact angleaaaaaaaaaa
Login to view more

Abstract

The present invention relates generally to methods and devices for the preparation of vesicles, including micelles, particularly liposomes, the method comprising extruding a solution containing a substance capable of forming vesicles through a mesh membrane under high pressure.

Description

[0001] This application claims the benefit of Provisional Application No. 60 / 326,032, filed September 28, 2001, under 35 U.S.C. §119, the entire contents of which are hereby incorporated by reference. field of invention [0002] The present invention relates generally to methods and methods for the preparation of vesicles, including micelles, especially liposomes, by extruding a solution containing material capable of forming vesicles through screen membranes under high pressure device. Background technique [0003] The use of liposomes for drug delivery has been proposed for a variety of drugs, especially those administered parenterally. Liposomes have the potential to provide controlled-release "dockets" of administered drugs over an extended period of time and have the potential to reduce drug side effects by limiting the concentration of free drug in the blood. Liposomes can also alter the tissue distribution and absorption of drugs in a therapeutically favorable manner...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/10A61K47/14B01J13/02B01J13/04
CPCA61K9/1277B01J13/04A61K9/127
Inventor K·R·希尔W·罗德里格扎G·A·西
Owner ESPERION THERAPEUTICS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap