New combination of Cefpirome Sulfate and preparation method

Abstract

A cefpirome sulfate as a newm edicine and its preparing process which features use of alkaline or neutral amino acid as cosolvent are disclosed.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a new composition of cefpirome sulfate and a preparation method thereof. Background technique [0002] Cefpirome sulfate is a fourth-generation cephalosporin antibiotic. Compared with the first, second, and third-generation cephalosporins, the fourth-generation cephalosporin has a broader antibacterial spectrum, is more stable to β-lactamase, and has a higher blood concentration. Can penetrate the blood-brain barrier and so on. It has been clinically proven to have a good effect on superficial secondary infections such as sepsis, trauma, and surgical trauma. Cefpirome has good bactericidal activity against the pathogenic bacteria of bacterial meningitis and has good penetration to the blood-brain barrier, so this product has achieved good curative effect in the treatment of meningitis infection. Although the half-life of cefpirome is relatively short (about 2h), the high con...

AI Technical Summary

Problems solved by technology

When using a double-chamber bag, there will undoubtedly be a certain amount of carbon dioxide entering the human body. Although it is not certain how harmful the carbon dioxide entering the body is, it is definitely not beneficial to the human body.