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Substances for preventing and treating autoimmune diseases

A technology for autoimmunity and diseases, applied in allergic diseases, metabolic diseases, gene therapy, etc., can solve problems that cannot be prevented and have no complete effect

Inactive Publication Date: 2005-09-28
LOMA LINDA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently used DNA-based vaccines are not fully effective in preventing the disease, and some of these vaccines, instead of preventing the disease, are associated with inducing or enhancing autoimmune responses

Method used

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  • Substances for preventing and treating autoimmune diseases
  • Substances for preventing and treating autoimmune diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0056] diabetes prevention

[0057] According to the present invention, the onset of diabetes in a patient can be delayed or prevented, as exemplified below. First, patients were selected on the basis of the presence of circulating anti-insulin and anti-GAD autoantibodies. Thereafter, give the patient an intramuscular injection of 0.05 mg / Kg body weight comprising the plasmid construction of the polynucleotide sequence SEQ ID NO: 1 encoding the pro-apoptotic protein BAX and the plasmid encoding the SEQ ID NO: 6 encoding SGAD The plasmid construction either comprises the polynucleotide sequence SEQ ID NO: 2 encoding the adenovirus protein E3-GP19k, or the plasmid construction comprises the polynucleotide sequence SEQ ID NO: 3 encoding ΔBCL-2.

[0058] The injections were repeated weekly for 3 weeks while the levels of circulating anti-insulin and anti-GAD autoantibodies were monitored. The treatment was discontinued when the levels of circulating anti-in...

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Abstract

A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoimmune disease or who has the autoimmune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding DeltaBCL-2.

Description

[0001] Statement of Federal Funding for Research and Development [0002] This invention was made with US Government support and under a cooperative agreement with the National Medical Technology Testbed, Inc. of the US Department of Defense (Agreement No. DAMD-17-97-2-7016), and thus the US Government has certain rights in the invention. [0003] Cross References to Related Applications [0004] This application claims the benefit of Provisional Application No. 60 / 401,652, filed August 6, 2002 in the United States, entitled "Methods and Materials for Inhibiting Diabetes," the contents of which are incorporated by reference in their entirety in this disclosure. technical background [0005] Autoimmune diseases are responsible for high morbidity and mortality in humans. These diseases include about 80 diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, which affect about 5 percent of Americans. Type 1 diabetes, an autoimmune disease, ...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K39/00A61K48/00C07H21/04C07K14/075C07K14/47C12N5/00
CPCA61K48/005A61K39/0008C07K14/4747C12N2840/203A61K2039/53C12N2710/10322C07K14/005C07K14/4713A61K38/1709A61K2039/55516A61K48/00C12N5/00C12N15/00C12N15/87A61P3/10A61P37/00A61P37/02A61P37/04A61P37/06A61P43/00
Inventor 艾伦·P·埃舍尔李逢春
Owner LOMA LINDA UNIVERSITY
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