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Compound drop pills with flavescent sophora root and its preparation method

A technology of sophora flavescens and dripping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients. Tract irritation symptoms, enhanced bioavailability, accelerated dissolution and absorption

Inactive Publication Date: 2005-11-23
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the limitations of existing injection preparation technology and the influence of the complexity of traditional Chinese medicine ingredients, traditional Chinese medicine injections are often prone to acute allergic reactions or adverse reactions. At the same time, there are also difficulties in operation, great pain for patients, high manufacturing and medical costs, and inconvenient transportation and storage. , heavy economic burden for patients, unsuitable for family use and other disadvantages
[0008] In addition, due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the drug efficacy. The play also directly affects the therapeutic effect
At the same time, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] Now with several groups of specific examples, the preparation method of compound Kushen dripping pills of the present invention will be further described.

[0032] [Group 1: Trials with a single substrate]

[0033] 1. Raw material: According to the preparation method 1, the dry powder containing the active pharmaceutical ingredients of traditional Chinese medicine Sophora flavescens and Baituling is prepared in advance for later use;

[0034] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 60000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0035]3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0036] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain Compound Kushen Dripping Pills with different specifications.

[0037] [...

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PUM

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Abstract

Disclosed is a dripping pill for treating cancer hemorrhage and having the functions of reducing fever, removing dampness by diuresis, detoxicating, removing obstruction and relieving pain. The objective of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects,and low cost. The composition is prepared from flavescent sophora root, carclazyte Siberian cocklebur as raw material, and medicinal carrying agent as the base material.

Description

technical field [0001] The present invention relates to a kind of medicinal composition with clearing away heat and promoting dampness, cooling blood and detoxification, dispelling stagnation and analgesia, and is used for the treatment of hemorrhage embolism of cancerous pain, especially relates to traditional Chinese medicine Sophora flavescens and Baituling as raw materials, and as substrate An oral preparation of a pharmaceutical composition prepared together with pharmaceutically acceptable carriers. Background technique [0002] According to the drug standard WS issued by the national ministry 3 -Compound Sophora flavescens injection prepared according to the formula and extraction process given in B-2752-97 is a pure traditional Chinese medicine injection for the treatment of bleeding and other diseases of cancer pain. It has been clinically verified for many years and has stable quality. The curative effect is definite, and it is a common drug used clinically and at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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