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CRH responsive genes in CNS

A technology of gene transcription and gene expression profiling, applied in the field of treatment and diagnosis of depression, can solve problems that have not been explored in the main field

Inactive Publication Date: 2005-12-14
JANSSEN PHARMA NV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] Although the downstream pathways of CRH-activated receptors have been extensively studied and led to the identification of many genes involved in the signaling cascade, one major area has not been explored

Method used

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  • CRH responsive genes in CNS
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Embodiment Construction

[0023] As used herein, the term "compound" or "agent" refers to a biological or chemical compound such as a simple or complex organic molecule, peptide, protein or oligonucleotide. A "test compound" as used herein refers to a "compound" or "agent" used in a method according to the invention to assess whether said compound modulates CRH signaling activity.

[0024] "CRH signaling" as used herein refers to a change in gene transcription in a cell following activation of the corticotropin releasing hormone receptor by CRH in said cell. It thereby induces a CRH-specific gene expression profile. Changes in transcript levels can be assessed at the protein or gene, RNA level.

[0025] "CRH responsive activity" as used herein generally refers to changes in detectable cellular parameters resulting from exposure of said cells to CRH. Detectable cellular parameters include changes in membrane potential, changes in the enzymatic activity of enzymes that regulate CRH signaling in said ce...

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Abstract

The present invention relates generally to therapy and diagnosis of depression. In particular this invention relates to the polypeptides as well as to the polynucleotides encoding these polypeptides, wherein said polypeptides are shown to play a central role in mediating the endocrine response to corticotropin releasing hormone. These polypeptides and polynucleotides are useful in the diagnosis, treatment and / or prevention of depression.

Description

[0001] The present invention relates generally to the treatment and diagnosis of depression. In particular, the present invention relates to polypeptides, and polynucleotides encoding these polypeptides, which have been shown to play a major role in mediating cellular responses to corticotropin releasing hormone. These polypeptides and polynucleotides can be used in the diagnosis, treatment and / or prevention of depression. Background of the invention [0002] Recent socioeconomic analyzes have found depression to be the leading cause of incapacity and a major risk factor for the development of other disorders. Furthermore, depression is underdiagnosed and undertreated on a worldwide scale. Recent antidepressants have proven effective, but suffer from a slow onset of action and a burden of side effects. On top of this, it remains unclear by which pharmacological mode of action they exert their clinical effects. Hypothesis-driven studies based on the corticosteroid receptor h...

Claims

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Application Information

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IPC IPC(8): C07K14/47C12Q1/68
CPCC07K14/47C12Q1/6883C12Q2600/158A61P25/24
Inventor P·J·彼得斯H·W·H·格尔曼S·M·A·斯瓦格马克斯S·U·卡斯T·H·W·斯特克勒F·L·P·费伦斯
Owner JANSSEN PHARMA NV
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