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Sustained release device and method for ocular delivery of adrenergic agents

An adrenaline, sustained release technology, applied in the direction of capsule delivery, drug delivery, pill delivery, etc., can solve the problem that it is difficult to achieve zero release

Inactive Publication Date: 2006-03-01
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, zero-shot release may be difficult to achieve with matrix systems

Method used

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  • Sustained release device and method for ocular delivery of adrenergic agents
  • Sustained release device and method for ocular delivery of adrenergic agents
  • Sustained release device and method for ocular delivery of adrenergic agents

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Embodiment Construction

[0025] The present invention provides devices and methods for delivering and maintaining a therapeutic amount of at least one adrenergic agent to the ciliary body of a patient's eye for an extended period of time. The device is a sustained release drug delivery device comprising at least one adrenergic agent capable of maintaining a therapeutically effective concentration of the adrenergic agent in the ciliary body for an extended period of time. The method includes inserting the device into or near the eye of the patient to deliver the adrenergic agent to the ciliary body.

[0026]The device of the invention may be adapted for insertion into the eye and between the eyelids, preferably the lower eyelids. In other embodiments it may be adapted for insertion into the subretinal anterior or posterior chamber, into the choroid, or into or on the sclera. In another embodiment, the device may be adapted for insertion into a lacrimal canaliculus. In another embodiment, the device m...

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PUM

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Abstract

The invention provides a device and method for treating and / or preventing raised intraocular pressure, such as that associated with glaucoma or the use of corticosteroids with adrenergic agents. The invention provides insertable sustained-release devices adapted to maintain a therapeutically effective concentration of one or more adrenergic agents for an extended period of time, and a method of use thereof.

Description

field of invention [0001] The present invention relates to the field of sustained delivery of drugs to the eye, and in particular to the treatment and / or prevention of elevated intraocular pressure, such as that associated with glaucoma or the use of corticosteroids, by sustained delivery of adrenergic agents to the eye. Background of the invention [0002] 1. Adrenergic agents [0003] Glaucoma is one of the leading causes of blindness in developed countries of the world. The main pathological feature of glaucoma is elevated intraocular pressure. Surgery and / or drugs aimed at lowering intraocular pressure are the most common treatments for glaucoma. The main drug therapy currently used is the administration of miotics (e.g., pilocarpine, carbachol, and echothiophate), which open the trabecular network to increase the rate of fluid flow out of the eye; PGF-2α analogs ( eg, unoprostone, travoprost, bimatoprost, and latanoprost), which enhance uveoscleral outflow; and carbo...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/00A61K9/32A61K9/50A61K31/382A61K31/542A61L27/34A61L27/54A61L31/10A61L31/16
CPCA61L27/34A61K9/5031A61L2300/602A61L2300/21A61K9/0092A61L31/16A61K31/382A61L31/10A61K31/542A61L27/54A61L2300/436A61K9/0051A61P27/06A61K9/209A61K9/28
Inventor 保罗·阿什顿郭红
Owner CONTROL DELIVERY SYST
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