Liuwei Dihuang effervescent tablet and its preparation thereof

A technology for Liuwei Dihuang and effervescent tablets is applied in the field of Liuwei Dihuang effervescent tablets and their preparation, and can solve the problems of difficulty in taking, large dosage, and slow over-effect time.

Inactive Publication Date: 2006-03-15
徐燕和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are reports on the clinical application, quality control, analysis of active ingredients, extraction technology and preparation production methods of Liuwei Dihuang traditional preparations, but Liuwei Dihuang effervescent tablets and related reports have not yet been seen.
[0015] The original dosage form of traditional Liuwei Dihuang Chinese patent medicine has many deficiencies. For example, although the honeyed pill has a high content of active ingredients, it is difficult to take in a large amount; loss, which affects the curative effect; although the preparation process of tablets, capsules, granules, etc. has been improved, the dosage is still too much, the taste is poor, and the super-effective time is slow, which affects the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Separately or mix 2.7 parts of Rehmannia glutinosa, 1.3 parts of Cornus officinalis, 1 part of Moutan cortex, 1.3 parts of Chinese yam, 1 part of Poria cocos, and 1 part of Alisma, and then steam distillation or supercritical carbon dioxide extraction technology, alcohol extraction and water extraction After the active ingredients are classified and extracted by methods such as methods, they are refined, filtered, concentrated, dried, and mixed to make Liuwei Dihuang extract powder or extract powder or granules. After mixing with disintegrants, fillers, binders, lubricants, and flavoring agents, it is granulated, dried, compressed into tablets, and packaged to make Liuwei Dihuang effervescent tablets.

[0048] Prescription composition:

[0049] Liuwei Dihuang Extract 25%;

[0050] Anhydrous Citric Acid 25%;

[0051] Sodium bicarbonate 10%;

[0052] Sodium carbonate 35%;

[0053] PEG6000 3.0%;

[0054] Lactose 20%;

[0055] Cyclamate 1.0%;

[0056] Sweet orange es...

Embodiment 2

[0060] Preparation method of Liuwei Dihuang extract:

[0061] Take 1 part of Moutan cortex, distill and extract the volatile oil, and collect the distilled aqueous solution in another device; take 1.3 parts of Cornus officinalis, extract twice with 70% ethanol under reflux, each time for 2 hours, combine the extracts, filter, and the filtrate is set aside. Take 2.7 parts of Rehmannia glutinosa, 1.3 parts of Chinese yam, and 1 part of Alisma, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, combine the filtrate with the above aqueous solution, and concentrate under reduced pressure to relative Clear ointment with a density of 1.15-1.20 (50°C thermal test), let it cool, add ethanol to make the ethanol content reach 70%, let it stand for 48 hours, take the supernatant and combine it with the above-mentioned Cornus officinalis extract, and recover the ethanol under reduced pressure until it is free of alcohol taste,...

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PUM

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Abstract

An effervescent tablet of six drugs including rehmannia is prepared from 6 Chinese-medicinal materials including prepared rehmannia root, tree peony bark, yam, tuckahoe, etc and the additive (disintegrant, lubricant, filler, adhesive and flavoring). Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a liuweidihuang effervescent tablet and a preparation method thereof. Background technique [0002] Effervescent tablet is a solid preparation for internal or external use that can rapidly generate bubbles (that is, boil) after being placed in water to make the tablet disintegrate rapidly. Its biggest feature is that the disintegrating agent is one or several organic acids (acid agent) and one or several kinds of acid can produce CO 2 Composed of inorganic salts (alkaline agents), which react with water to produce acid-base neutralization and release CO 2 Disintegrate the tablet. As a new type of preparation, effervescent tablets have the following characteristics: [0003] 1. Its production, transportation, and storage are in solid form, so it has the characteristics of accurate dosage of solid preparations, stable quality, high degree of production automation, low cost, and easy to carry; [0004] 2. Effervescent tablets ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K36/804A61K9/20A61K9/46A61P1/14A61P15/12A61P9/12A61P9/10A61P3/10A61P19/10A61P13/12A61P25/20A61P11/04
Inventor 徐燕和
Owner 徐燕和
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