Combined use of ribavirin and interferon beta in demyelinating diseases
A kind of technology of interferon, application, application in the field of the compound represented by general formula, treatment and/or prevention of demyelinating diseases such as multiple sclerosis
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[0145] Effects of ribavirin alone or in combination with IFN-β in in vivo models of multiple sclerosis
[0146] The established multiple sclerosis (MS) animal model was used to analyze the effect of ribavirin alone or in combination with IFN-β on disease development. The experimental autoimmune encephalomyelitis (EAE) model is a mouse model of chronic demyelination. The method used to induce EAE in mice was adapted from the protocol published by Sahrbacher et al. (1998).
[0147] EAE Induction Protocol
[0148] mouse
[0149] Breed, strain, substrain and sex: C57 BL / 6JICO female mice from the colony of IFFA CREDO (Saint Germain sur l'Arbresle, France) were provided by Charles River Italia (Calco, Lecco, Italy).
[0150] Age and weight (random): about 8 weeks old; 18-22g
[0151] Housing: Animals were housed in cages as follows:
[0152] - 10 animals per cage, placed in an air-conditioned room
[0153] -Temperature: 22℃±2
[0154] -Relative Humidity: 55%±10
[0155] - ...
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