Vaccine against mumps containing a JERYL-LYNN virus strain
A technology for mumps virus strains and vaccines, applied to medical preparations containing active ingredients, viruses/bacteriophages, antibody medical components, etc., which can solve problems such as difficult to estimate ratios and inability to ensure balance
Inactive Publication Date: 2010-12-01
GLAXOSMITHKLINE BIOLOGICALS SA
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Problems solved by technology
However, as the Jeryl-Lynn strain is further passaged, there is no guarantee that this balance between the two variants will be maintained
It is also difficult to estimate the proportion of these two variants in any batch of vaccines
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The present invention provides a new mumps vaccine comprising a homogeneous pure isolate derived from the Jeryl-Lynn strain of mumps virus. In a preferred embodiment of the invention the vaccine produces higher seroconversion and antibody titres than known commercial vaccines.
Description
Vaccine against mumps containing the JERYL-LYNN strain related application This application is a divisional application of Chinese patent application 94194807.2 submitted to China Patent Office on July 10, 1996. technical field The present invention relates to a mumps vaccine comprising a homogeneous purified isolate derived from the Jeryl-Lynn strain of mumps virus. Background technique Mumps is basically a disease of children, usually with mild clinical symptoms. However, the clinical consequences of mumps infection are severe in some cases. For example, mumps is the most common cause of meningoencephalitis in children under 15 years of age and a cause of permanent sensorineural deafness in children in the United Kingdom. Although 30-40% of natural mumps infections are asymptomatic, the salivary glands are involved and, in the adult population, mumps causes first trimester abortion in addition to the neurological complications mentioned above and orchitis, these ar...
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IPC IPC(8): C12N7/00A61K39/165A61KC12N
Inventor 奈杰尔·M·哈福德布里格特·D·A·科劳让·迪德莱兹
Owner GLAXOSMITHKLINE BIOLOGICALS SA
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