Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method of preparing 3'-chlorophenyl acetone

A technology of chloropropiophenone and propiophenone, which is applied in the preparation of carbon-based compounds, chemical instruments and methods, preparation of organic compounds, etc., can solve the problems of NO exhaust emission, harmful to human health, and difficult matching, and achieves good selectivity, Highly active effect

Inactive Publication Date: 2006-06-14
潘国平
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The raw materials used in this method are m-aminopropiophenone and sodium nitrite, wherein m-aminopropiophenone is an unconventional chemical, and it is difficult to form a complete set. Sodium nitrite and cuprous chloride are carcinogens, and long-term exposure is harmful to human health, and The diazotization yield of this reaction is low, the separation of the target is complicated, a large amount of waste liquid is produced after the reaction, and NO waste gas will be discharged during the reaction, and the discharge will pollute the environment. Therefore, this method is very popular. big limit

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of preparing 3'-chlorophenyl acetone
  • Method of preparing 3'-chlorophenyl acetone
  • Method of preparing 3'-chlorophenyl acetone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] Below with preparing 550 kilograms of 3 '-chloropropiophenones as an example to illustrate the concrete preparation process of the present invention.

[0024] Prepare materials: Take 500kg of propiophenone, 600kg of aluminum trichloride, 350kg of solvent 1,2-dichloroethane, sufficient chlorine Cl 2 : Its preparation reaction equation is:

[0025]

[0026] Propiophenone: Molecular formula is C 9 h 10 O, the molecular weight is 134;

[0027] Physical and chemical properties: leaf-like crystals or colorless to light amber liquid, with a strong and lasting aroma, can be mixed with methanol, ether, benzene, toluene, etc., insoluble in water, ethylene glycol, propylene glycol and glycerin, specific gravity 1.0105 (20 / 4 ℃), melting point mp: 21 ℃, boiling point 218 ℃, flash point 210 ℃ open cup.

[0028] Aluminum trichloride: Molecular formula is AlCl 3 , the molecular weight is 133.5;

[0029] Physical and chemical properties: yellowish crystal or powder, with a stro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a preparation method of 3í»-chlorophenylacetone. Said invention uses phenylacetone and chlorine gas Cl2 as initial raw material, uses aluminium trichloride as catalyst, uses 1,2-ethylene dichloride as solvent and makes them undergo the processes of chloridization, low-temperature hydrolysis, water-washing and stratification, reduced pressure distillation and rectification so as to obtain the invented 3í»-chlorophenylacetone finished product whose content is 99.7%-99.9%, and whose yield is 88%-90%.

Description

Technical field: [0001] The present invention relates to a kind of preparation method of 3'-chloropropiophenone. Background technique: [0002] 3'-chloropropiophenone is a key intermediate for the synthesis of bupropion hydrochloride. Bupropion hydrochloride is an antidepressant, which is a blocker for weak neurons to absorb 5-hydroxytryptamine and norepinephrine. It is suitable for patients who have no clear effect on other depression drugs or who cannot tolerate depression. Bupropion can also be used as an adjunctive treatment for smoking cessation, viral infections, or sexual dysfunction. [0003] Its chemical name is: 3'-chloropropiophenone; molecular formula: C 9 h 9 ClO; molecular weight is 168.5; [0004] The structural formula is: [0005] [0006] Physical and chemical properties: Appearance is white crystalline powder, melting point mp: 45-47°C, easily soluble in polar solvents. At present, the usual method for preparing 3'-chloropropiophenone is: m-aminop...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C49/807C07C45/63
Inventor 潘国平
Owner 潘国平
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com