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Gel containing centella general glycoside and sodium hyaluronate for preparing drop and spray agent

A technology of total asiaticosides and sodium hyaluronate, which is applied to medical preparations containing active ingredients, aerosol delivery, organic active ingredients, etc., to achieve the effects of low raw material cost, large market demand, and simple preparation process

Inactive Publication Date: 2010-05-05
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the wound surface of some trauma patients should not be directly coated with glue

Method used

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  • Gel containing centella general glycoside and sodium hyaluronate for preparing drop and spray agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1 asiaticoside-sodium hyaluronate gel drops:

[0054] formula:

[0055] Centella asiaticoside 1.5g

[0056] Sodium Hyaluronate 0.3g

[0057] Sodium chloride 0.5g

[0058] Methyl benzoate 0.1g

[0059] Propyl benzoate 0.01g

[0060] Propylene glycol 0.1g

[0061] Anhydrous sodium dihydrogen phosphate 0.7g

[0062] Anhydrous disodium hydrogen phosphate 0.1g

[0063] borneol 0.02g

[0064] Distilled water 100ml

[0065] Configuration method:

[0066] 1. Weigh asiaticoside according to the formula, dissolve an appropriate amount in the buffer solution containing stabilizer and cooling agent, and wait until it is completely dissolved.

[0067] 2. Weigh sodium hyaluronate according to the formula, dissolve it in the solution containing preservatives and osmotic pressure regulators, and let it stand overnight until completely dissolved.

[0068] 3. Under slow stirring, slowly add the asiaticoside solution into the sodium hyaluronate solution until fully u...

Embodiment 2

[0070] Embodiment 2 asiaticoside-sodium hyaluronate gel spray:

[0071] formula:

[0072] Centella asiaticoside 2.4g

[0073] Sodium Hyaluronate 0.6g

[0074] Sodium chloride 1.5g

[0075]Benzalkonium Chloride 0.01g

[0076] Polyethylene glycol 1.0g

[0077] Boric acid 1.2g

[0078] Borax 0.06g

[0079] Menthol 0.01g

[0080] Distilled water: 100ml

[0081] Configuration method: 1-3 is the same as embodiment 1

[0082] 4. Dispensed in quantitative spray bottles.

Embodiment 3

[0084] Formula: other components and configuration method are all the same as example 2, but

[0085] Centella asiaticoside 4.0g

[0086] Sodium Hyaluronate 0.5g

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Abstract

The present invention belongs to the field of medicine preparation technology, and is one kind of gel dripping preparation and aerosol containing asiaticoside and sodium hyaluronate. The gel drippingpreparation and aerosol is different from gel preparation in that it can form one film on the surface of wound. The gel dripping preparation and aerosol is relatively thin, easy to form film on wound,and suitable for wound of patient incapable of being painted with gel directly. The present invention also provides the preparation process.

Description

Technical field: [0001] The invention belongs to the field of pharmacy. Specifically, it relates to a gel containing asiaticoside and sodium hyaluronate for the preparation of drops or sprays. Background technique: [0002] Asiaticoside is a pentacyclic triterpenoid compound extracted and refined from Centella asiatica, mainly containing Asiaticoside and Madecassoside. Application of asiaticoside in various wounds can accelerate the formation of wound granulation tissue, promote wound healing, inhibit the disordered proliferation of fibroblasts, and reduce scars. Asiaticoside cream can only be used after the wound surface is repaired, and its main function is to prevent scar hyperplasia. [0003] Sodium hyaluronate is a high-molecular polysaccharide, which is composed of a molecule of acetylglucosamine and glucuronic acid. Because of its three-dimensional structure, it has good elasticity, lubricity and biocompatibility, and can form a smooth and breathable film on the su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/715A61K9/00A61K9/12A61P17/02
Inventor 崔明顾敏
Owner SHANGHAI INST OF PHARMA IND CO LTD
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