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Medicinal preparation containing volatile oil and preparing method thereof

A technology of pharmaceutical preparations and volatile oils, which is applied in the field of medicine, can solve the problems of shortened validity period, lower drug efficacy, and high cost, and achieve the effects of less loss of volatile oils, reduced dosage, and low production costs

Inactive Publication Date: 2006-06-21
李文军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation produced by this method, because the volatile oil is not closely combined with the absorbent, it is easy to volatilize when it is made into a preparation, resulting in a decrease in drug efficacy and a shortened validity period; Generally, it is relatively large and inconvenient to take
[0006] Some also use cyclodextrin inclusion method to prepare cyclodextrin-volatile oil inclusion compound, but this method is not easy to operate, complicated process, and requires special equipment in industrial production, resulting in low efficiency and low product yield. The loss of volatile oil is serious, and the amount of cyclodextrin is relatively large, generally 8-10 times the amount of volatile oil, resulting in a large amount of consumption and an increase in cost
[0007] There is also a method of making volatile oil into microcapsules first, and then making various preparations, but this method is complex in process, requires special equipment, low yield, high cost, and the process is not yet fully mature.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The composition and weight percentage of this embodiment are: 20% peppermint oil and 80% polyethylene glycol 4000.

[0029] Tablets are prepared by a process comprising the following steps:

[0030] (1) solidified volatile oil: take the polyethylene glycol 4000 of the proportioning, heat and melt, add the peppermint oil of the proportioning while stirring, mix and cool for later use;

[0031] (2) Preparation: pulverize the solidified peppermint oil, and then press it into a tablet.

[0032] Make hard capsules by the method comprising the following steps:

[0033] (1) solidified volatile oil: take the polyethylene glycol 4000 of the proportioning, heat and melt, add the peppermint oil of the proportioning while stirring, mix and cool for later use;

[0034] (2) Preparation: pulverize the solidified peppermint oil, put it into a capsule shell and make a hard capsule.

[0035] Prepare granules by a method comprising the following steps:

[0036] (1) solidified volatile...

Embodiment 2

[0039] The composition and weight percentage of the present embodiment are: 5% zedoary oil and 95% polyethylene glycol 6000.

[0040] Tablets are made by the method comprising the following steps: take the polyethylene glycol 6000 of the proportioning, heat and melt, add the curcuma oil of the proportioning while stirring, inject the tablet mold while hot after mixing, and Just take it out.

[0041] Make hard capsules by the method comprising the following steps:

[0042] (1) Solidified volatile oil: take the polyethylene glycol 6000 of the proportioning, heat and melt, add the Zedoary Curcuma Oil of the proportioning while stirring, mix and cool for subsequent use;

[0043] (2) Prepare preparation: pulverize cured curcuma oil, put it into capsule shell to make hard capsule.

[0044] Prepare granules by a method comprising the following steps:

[0045] (1) Solidified volatile oil: take the polyethylene glycol 6000 of the proportioning, heat and melt, add the Zedoary Curcuma...

Embodiment 3

[0048] The composition and weight percentage of this embodiment are: 50% orange peel oil and 50% polyethylene glycol 2500.

[0049] Tablets are prepared by a process comprising the following steps:

[0050] (1) solidified volatile oil: get the polyethylene glycol 2500 of described proportion, heat and melt, add the tangerine peel oil of described proportion while stirring, mix and cool for subsequent use;

[0051] (2) Prepare a preparation: pulverize the cured tangerine peel oil, press it into a tablet, and then wrap a layer of film coat on its surface.

[0052] Make hard capsules by the method comprising the following steps:

[0053] (1) solidified volatile oil: get the polyethylene glycol 2500 of described proportion, heat and melt, add the tangerine peel oil of described proportion while stirring, mix and cool for subsequent use;

[0054] (2) Preparation: pulverize the cured tangerine peel oil, put it into a capsule shell and make a hard capsule.

[0055] Prepare granules ...

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Abstract

The present invention discloses one kind of medicine preparation containing volatile oil and medicinal supplementary material capable of solidifying the volatile oil. The medicine preparation is tablet, capsule or granule, and the medicinal supplementary material is polyglycol of average molecular weight over 2500. The volatile oil in the medicine preparation may be well maintained, and so does the medicine effect. The present invention also discloses the preparation process of the medicine preparation.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical preparation containing volatile oil and a preparation method of the pharmaceutical preparation. Background technique [0002] When producing tablets containing a large amount of volatile oil, there are many shortcomings such as poor molding, loose tablets, and poor hardness during tablet compression. Because such ingredients can reduce the cohesion between particles, only volatile oil is removed during production to reduce the volatile oil content in the particles. Increase the cohesion and improve the hardness of the tablet, but if the volatile oil is the effective substance, it should not be removed, otherwise it will lead to a decrease in the efficacy of the drug. [0003] When producing hard capsules containing a large amount of volatile oil, if the volatile oil is not processed, the medicine in the capsule will easily harden into a block, which will slow do...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K9/16A61K9/20A61K9/48A61K47/10
Inventor 李文军
Owner 李文军