Reproduction toxicity detection and evaluation method of pharmaceutical waste water

Abstract

A method for detecting and evaluating reproductive toxicity of waste water from pharmaceutical factory includes using mouse as test animal and contaminating it by orally force ¿C taking waste water, observing mouse sperm form after test period is expired and calculating sperm deformity rate, analyzing percentage of various spermatogenous cell, carrying out differential significance detection of comtaminated group to reference group and using detection result to evaluate toxicity of pharmaceutical factory waste water to mouse sperm.

Description

1. Technical field [0001] The invention relates to a toxicity detection and evaluation method of pharmaceutical wastewater, more specifically a reproductive toxicity detection and evaluation method of pharmaceutical wastewater. 2. Background technology [0002] There are many ways to evaluate the toxicity of poisons. There are already domestic and international methods to evaluate the toxicity of poisons by detecting the sperm morphology of tested animals. Beijing Medical University used vinyl chloride to inhale the mice, observe the sperm morphology, and calculate Deformation rate, evaluation of its toxicity. Quinto I et al. poisoned mice by intraperitoneal injection with poisons such as methiron and imophos, then observed the morphology of sperm and calculated the deformity rate. There is no relevant literature on the detection of the toxicity of synthetic pharmaceutical wastewater by testing the morphology of mouse sperm and the percentage of spermatogenic cells, and the...

AI Technical Summary

Problems solved by technology

The production wastewater of some pharmaceutical factories contains a large number of organic substances, especially the pharmaceutical factories that synthesize and produce neuromodulatory drugs. The wastewater contains organic chlorine and other organic pollutants such as benzene rings and heterocyclic rings, among which persistent organic pollutants POPs ( Persistent organic pollutants) and environmental hormone EH (environmental hormone) are as many as more than a dozen pollutants, but the biological toxicity of this wastewater and its harm to human health and ecological safety are still unclear

Since conventional detection methods and emission standards are not enough to accurately detect and evaluate the biomolecular toxicity of POPs and EH, it is still a major international problem to evaluate the environmental health risks and ecological safety risks of POPs and EH

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