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Azlocillin/sulbactam antibacterial composition

A technology of azlocillin and azlocillin sodium, which is applied in the direction of antibacterial drugs, active ingredients of heterocyclic compounds, etc., can solve the problems of general antibacterial effect, and achieve the effect of mature and perfect process equipment and easy industrial production

Inactive Publication Date: 2006-09-27
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although each specific drug in the semi-synthetic penicillin antibacterial drugs can be said to have a broad antibacterial spectrum and strong antibacterial effect, in fact it can only be highly active against a certain type, or certain types of bacteria, while it is only active against other bacteria. general antimicrobial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Under aseptic and clean conditions, 20 kilograms of azlocillin sodium (calculated as azlocillin) and 10 kilograms of sulbactam sodium (calculated as active acid) were mixed, and this product was prepared according to the preparation process of freeze-dried powder injection. Invention of powder injection.

Embodiment 2

[0019] Embodiment 2: Under aseptic and clean conditions, 10 kilograms of azlocillin sodium (calculated as azlocillin) and 1.25 kilograms of sulbactam sodium (calculated as active acid) were mixed, and this product was prepared according to the freeze-dried powder injection preparation process procedure. Invention of powder injection.

Embodiment 3

[0020] Embodiment 3: Under aseptic and clean conditions, 10 kilograms of azlocillin sodium (calculated by azlocillin) and 10 kilograms of sulbactam sodium (calculated by active acid) are mixed, and the powder of the present invention is prepared according to the powder injection preparation process procedure injection.

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PUM

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Abstract

The present invention belongs to the field of medicine technology, relates to compound antibiotic medicine capable of inhibiting bacteria produced beta-lactamase, and is especially compound antibiotic azlocillin / sulbactam medicine. The compound antibiotic azlocillin / sulbactam medicine is compounded with azlocillin and sulbactam or its derivative in the weight ratio of 1-16 as the active components. Azlocillin and sulbactam in the compound medicine has obvious synergistic effect, and the compound medicine can inhibit the activity of beta-lactamase and protect azlocillin against the destruction of bacteria produced beta-lactamase, is favorable to the antibiotic effect of azlocillin in strengthen antibiotic activity, widened antibiotic spectrum, less resistance and raised clinical treating effect.

Description

technical field [0001] The invention relates to an antibiotic compound drug for inhibiting β-lactamase produced by bacteria, and belongs to the technical field of drugs. Background technique [0002] Semi-synthetic penicillin antibiotics have been widely used clinically, and have achieved therapeutic effects that are difficult to achieve with traditional antibiotics. However, due to the long-term and extensive clinical use of antibiotics, and even the abuse of antibiotics, bacteria have become increasingly resistant to antibiotics. Azlocillin is a semi-synthetic penicillin antibiotic commonly used in clinical practice. + Bacteria include Staphylococcus aureus, Streptococcus faecalis, Pseudomonas, Escherichia coli, Pneumococcus, Proteus, Enterobacter, Citrobacter, Serratia, Acinetobacter, and penicillin-sensitive Gram-positive cocci have antibacterial effect, and large doses have bactericidal effect; - Bacteria including Pseudomonas aeruginosa, Escherichia coli, Enterobact...

Claims

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Application Information

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IPC IPC(8): A61K31/431A61P31/04A61K31/43
Inventor 赵玉山何茂群任正伟李广王子伟段祥永
Owner REYOUNG PHARMA
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