Azlocillin/sulbactam antibacterial composition

Abstract

The present invention belongs to the field of medicine technology, relates to compound antibiotic medicine capable of inhibiting bacteria produced beta-lactamase, and is especially compound antibiotic azlocillin / sulbactam medicine. The compound antibiotic azlocillin / sulbactam medicine is compounded with azlocillin and sulbactam or its derivative in the weight ratio of 1-16 as the active components. Azlocillin and sulbactam in the compound medicine has obvious synergistic effect, and the compound medicine can inhibit the activity of beta-lactamase and protect azlocillin against the destruction of bacteria produced beta-lactamase, is favorable to the antibiotic effect of azlocillin in strengthen antibiotic activity, widened antibiotic spectrum, less resistance and raised clinical treating effect.

Description

technical field

[0001] The invention relates to an antibiotic compound drug for inhibiting β-lactamase produced by bacteria, and belongs to the technical field of drugs. Background technique

[0002] Semi-synthetic penicillin antibiotics have been widely used clinically, and have achieved therapeutic effects that are difficult to achieve with traditional antibiotics. However, due to the long-term and extensive clinical use of antibiotics, and even the abuse of antibiotics, bacteria have become increasingly resistant to antibiotics. Azlocillin is a semi-synthetic penicillin antibiotic commonly used in clinical practice. + Bacteria include Staphylococcus aureus, Streptococcus faecalis, Pseudomonas, Escherichia coli, Pneumococcus, Proteus, Enterobacter, Citrobacter, Serratia, Acinetobacter, and penicillin-sensitive Gram-positive cocci have antibacterial effect, and large doses have bactericidal effect; - Bacteria including Pseudomonas aeruginosa, Escherichia coli, Enterobact...