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Use of catechu in preparing drug for treating hyperuricemia

A technology of hyperuricemia and catechu, which is applied in the field of medicine, can solve the problems of inhibiting bone marrow function, gastrointestinal reactions, allergic drug eruption, clinical application limitations, and human side effects, so as to relieve joint redness and pain, and relieve muscle soreness and joint pain Effect of reducing swelling and hyperuricemia

Inactive Publication Date: 2006-09-27
张廷模
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Probesulfonamide, a drug that promotes uric acid excretion, can promote renal tubular excretion of uric acid to relieve hyperuricemia, but this product also has the side effects of general sulfonamides.
Although the xanthine inhibitor allopurinol can reduce the production and synthesis of uric acid in the body to alleviate hyperuricemia, it can inhibit bone marrow function and have side effects such as greater gastrointestinal reactions and allergic drug eruptions.
Due to the above adverse reactions of Western medicine for the treatment of gout, if taken in large quantities or for a long time, it is very easy to cause relatively serious toxic and side effects on the human body, which greatly limits its clinical application
At present, there is no report on the treatment of hyperuricemia and gout by catechu

Method used

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  • Use of catechu in preparing drug for treating hyperuricemia

Examples

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Effect test

Embodiment 1

[0025] Embodiment 1 Preparation of catechin extract of the present invention

[0026] Preparation of water extract of catechu: take 500g catechu, add ten times the amount of water to decoct twice, 1 hour each time, combine the two medicinal liquids after filtration, and concentrate under reduced pressure with a rotary evaporator until the medicinal liquid contains 1g of crude drug per ml.

[0027] Preparation of catechin alcohol extract: take 500g catechin, add ten times the amount of 95% ethanol, reflux extraction twice, each time for 1 hour, combine the two medicinal liquids after filtration, and concentrate under reduced pressure with a rotary evaporator to the concentration of each ml medicinal liquid Contains crude drug 1g.

Embodiment 2

[0028] Example 2 The preparation of the pharmaceutical composition containing catechin in the raw material of the present invention

[0029] Preparation of water extract: Take 80g each of catechu, chebula, frankincense, Phellodendron Phellodendron, add 200g of Gentiana chinensis, and 240g of Qinpi 240g, add ten times the amount of water and decoct 2 times, each time for 1 hour, combine the two medicines after filtering, and use a rotating Concentrate under reduced pressure in an evaporator to contain 1 g of crude drug per ml of liquid medicine.

[0030] Preparation of alcohol extract: take 80g each of catechu, chebula, frankincense, Phellodendron Phellodendron, 200g of Gentiana, 240g of Gentiana, add ten times the amount of 95% ethanol, reflux extraction twice, each time for 1 hour, and combine the two medicines after filtration , Concentrate under reduced pressure with a rotary evaporator to contain 1 g of crude drug per ml of liquid medicine.

Embodiment 3

[0031] Example 3 Preparation of the pharmaceutical composition containing catechin in the raw material of the present invention

[0032] Take 80g of catechu, 27g of myrobalan, 27g of frankincense, 27g of Cortex Phellodendri, 107g of Gentiana chinensis, and 133g of Qinpi, and prepare it according to the water extraction method or alcohol extraction method described in Example 2, add starch and dextrin, granulate, granulate, and pack , to obtain granules.

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Abstract

The present invention provides new use of catechu in preparing medicine for treating hyperuricemia, medicine composition containing catechu and its preparation process and use. The medicine of the present invention can lower uric acid content in blood and treat gouty arthritis and has less bad reaction and high safety.

Description

technical field [0001] The invention relates to a new application of medicine, specifically, the application of catechu in the preparation of medicine for treating hyperuricemia, which belongs to the field of medicine. Background technique [0002] Hyperuricemia is due to purine metabolism disorder, increased uric acid production and / or decreased uric acid excretion, so that the blood uric acid concentration exceeds the upper limit of the normal value, and the blood uric acid concentration (serum, uricase method) of normal people fluctuates within a narrow range, male It is 0.15-0.38mmol / L (2.4-6.4mg / dl), and it is 0.1-0.3mmol / L (1.6-5.2mg / dl) for women before menopause. After menopause, the value of female is close to that of male. Epidemiological studies suggest that when blood uric acid exceeds 0.42mmol / L (7.0mg / dl), it is hyperuricemia. Gout is an inflammatory response caused by long-term purine metabolic disorders, increased uric acid production, decreased uric acid e...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K36/756A61P19/06
Inventor 张廷模孙晓波
Owner 张廷模
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