Sodium hyaluronate carulon fat emulsion formulation and its uses

A technology of sodium hyaluronate and dexamethasone, which is applied in the field of medicine, can solve the problems of lack of radical measures and medicines, and achieve the effect of improving bioavailability, strengthening treatment effect, and small particle size

Active Publication Date: 2006-10-11
XIAN LIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Clinically, there is still a lack of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of low-content dexamethasone palmitate fat emulsion (0.1mg·ml -1 Dexamethasone Palmitate)

[0034] Dexamethasone Palmitate

[0035] Take 99g of soybean oil, add 12g of lecithin, heat to 75°C under nitrogen protection, stir for about 10min to fully dissolve the lecithin, then add 100mg of dexamethasone palmitate and 20ml of vitamin E, dissolve and mix well. Another 800ml of water for injection was taken, and 22g of glycerol was added. Under the condition of nitrogen protection, add dexamethasone palmitate phospholipid oil solution into glycerin aqueous solution to make colostrum, then add 10ml sodium hyaluronate, mix well, and adjust the total amount to 1000ml. The high-pressure homogenizer homogenizes 7-8 times, the homogenization pressure is 100MPa, and the particle size ranges from 180nm to 300nm, adjusts the pH to 7.0-8.0, filters, subpackages, injects nitrogen, and seals. Sterilize at 115°C for 30 minutes, after passing the light inspection...

Embodiment 2

[0037] Preparation of high-content dexamethasone palmitate fat emulsion (40mg·ml -1 Dexamethasone Palmitate)

[0038] Dexamethasone Palmitate

[0039]Take 99g of soybean oil, add 12g of lecithin, heat to 75°C under nitrogen protection, stir for about 10min to fully dissolve the lecithin, then add 40g of dexamethasone palmitate and 20ml of vitamin E, dissolve and mix well. Another 800ml of water for injection was taken, and 22g of glycerol was added. Under the condition of nitrogen protection, add dexamethasone palmitate phospholipid oil solution into glycerin aqueous solution to make colostrum, then add 10ml sodium hyaluronate, mix well, and adjust the total amount to 1000ml. The high-pressure homogenizer homogenizes 7-8 times, the homogenization pressure is 100MPa, and the particle size ranges from 180nm to 300nm, adjusts the pH to 7.0-8.0, filters, subpackages, injects nitrogen, and seals. Sterilize at 115°C for 30 minutes, after passing the light inspection, pac...

Embodiment 3

[0042] The preparation method is the same as in Example 2.

[0043] 2. Fat emulsion preparations with different concentrations of sodium hyaluronate (only dexamethasone palmitate is used as an example)

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PUM

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Abstract

The invention discloses the formulation of sodium hyaluronate aeroseb-D intralipid and the application in preparing medicine treating arthritis. The main components contained in formulation are aeroseb-D or its derivant, lecithin used as emulsion packing material and slow-releasing agent, sodium hyaluronate used as stabilizing agent for emulation, lubricant for soft tissue and bone and joint and anti-inflammation adjuvant, and vitamin E used as antioxidant. The emulation makes use of technology of medicine-delivery by emulation and function of lubricating and disinfecting soft tissue by sodium hyaluronate, and the adhesive degree and stability of emulation is dramatically increased, the slow-releasing property is prolonged, anti-inflammatory action is enhanced, and pain caused by arthritis is effectively reduced. The good bioavailability of said emulation enables complete metabolism in human body and the side effect is little.

Description

technical field [0001] The invention relates to a medicine, in particular to a sodium hyaluronate dexamethasone fat emulsion preparation, which can be used as a medicine for treating arthritis. Background technique [0002] Osteoarthritis (OA) is a chronic degenerative joint disease caused by various reasons, characterized by degeneration and destruction of articular cartilage and bone hyperplasia. [1] . Its onset is related to various factors such as age, body weight, inflammation, trauma, genetics, etc. There is no obvious regional and racial difference, and it is one of the important causes of human disability [2] . Clinically, there is still a lack of effective radical measures and drugs. [0003] The following are the references given by the inventor after retrieval: [0004] [1] Hunter DJ, Felson DT. Osteoarthritis. BMJ. 2006. Mar 18; 332(7542): 639-42. [0005] [2] Anderson JJ, Felson DT. Factors associated with osteoarthritis of the kn...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/56A61K31/355A61K47/24A61K47/36A61P19/02
Inventor 陈涛王汝涛
Owner XIAN LIBANG PHARMA
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