Molecular blotting solid phase microextraction coating preparation method

A technology of molecular imprinting and extraction, which is applied in separation methods, solvent extraction, chemical instruments and methods, etc., can solve the problems of poor repeatability of coating methods, combined use, and poor practicability, so as to improve stability and reduce diffusion resistance , the effect of increasing the specific surface area

Inactive Publication Date: 2006-10-11
SUN YAT SEN UNIV
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Problems solved by technology

However, the thickness of the coating cannot be controlled, and the repeatability of the coating method is poor (RSD≈15%), and the SPME extraction head prepared by this method cannot be used in conjunction with liquid chromatography, so the practicability is not strong

Method used

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  • Molecular blotting solid phase microextraction coating preparation method
  • Molecular blotting solid phase microextraction coating preparation method
  • Molecular blotting solid phase microextraction coating preparation method

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Embodiment Construction

[0023]In this embodiment, the present invention is described in detail by taking promethazine as an example, but this does not limit the protection scope of the present invention.

[0024] like figure 1 As shown, the preparation method of the molecularly imprinted solid-phase microextraction coating of procytidine is as follows:

[0025] (1) Soak the quartz fiber in 1.0mol / L NaOH alkaline washing solution at room temperature for 1 hour, take it out, and rinse it with distilled water three times; the quartz fiber after alkali washing is then soaked in 1.0mol / L HCl pickling solution for 1 hour , take it out, rinse it with distilled water, remove the residual HCl on the surface, put it into a petri dish and place it in an oven at 150°C for activation for 1 hour. Take out the quartz fiber from the oven, put it into 10% (V / V) 3-methacryloyl-propyl-trimethoxysilane silicone acetone solution immediately, take it out after silanization reaction for 1 hour, rinse with methanol three t...

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Abstract

The invention discloses a method for preparing the molecular engram solid phase micro-extraction coat, which comprises following steps: alkali cleaning, acid cleaning, activating and silanizing quartz fiber; assembling the template molecular and functional nomomer; adding crosslinking agnet and initiator, inserting silanized quartz molecular and thermally initiating the polymerization; extracting out the fiber to be aged; repeating aforementioned steps to reach needed thickness of coat; washing and removing the template molecular. Compared with commercial coat, the Prometryne molecular engram solid phase micro-extraction coat prepared by said method has better molecular recognition function on the triazine herbicide, while said coat is in porous structure without broken in long service. And its thickness can be adjusted via the plating times with better repeating ability. The extracting head can be used with the liquid chromatography, to separated and collect the triazine herbicide in the complex base as environment sample and food.

Description

technical field [0001] The invention belongs to the field of chemical analysis testing instruments, and relates to a preparation method of a molecularly imprinted solid-phase microextraction coating. It is suitable for the separation and enrichment of imprinted molecules and a class of compounds with similar structures in complex matrices such as biology, medicine, environmental samples and food. Background technique [0002] The analysis of trace and ultra-trace substances in complex matrices such as biological, pharmaceutical, environmental samples and food depends on efficient and highly selective sample pretreatment technology. During chromatographic analysis, sample pretreatment is usually the most time-consuming and difficult-to-automate step, and is currently recognized as the most critical step. However, compared with the development of instrumental analysis technology, the progress of sample pretreatment technology has been relatively slow. [0003] In 1989, Belar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/00B01D15/08G01N30/08
Inventor 李攻科胡小刚胡玉玲
Owner SUN YAT SEN UNIV
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