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Method for making and finding new farm-chemical by using clustering effect principle

A technology based on pesticides and principles, applied in botany equipment and methods, applications, animal repellants, etc., can solve problems such as huge consumption of manpower and material resources, long time, and weak core competitiveness

Inactive Publication Date: 2006-10-25
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the creation of a new type of pesticide, from the original basic research to the industrialization, requires the full investment of strong financial and material resources and innovative scientific and technological personnel, which consumes a lot of manpower and material resources and takes a long time.
Although our country has made great achievements in the development and production of pesticides, there are very few products with market exclusivity, strong competitiveness and independent intellectual property rights, and the core competitiveness is not strong.
However, there is no report on the application of this principle in the creation of new pesticide varieties.

Method used

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  • Method for making and finding new farm-chemical by using clustering effect principle
  • Method for making and finding new farm-chemical by using clustering effect principle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: The research on abamectin and its derivatives is an active field, and it has been developed to include ivermectin, emamectin benzoate, acetamidoabamectin, Dao A series of veterinary drugs and pesticides such as laramectin, among which emamectin benzoate (amamectin benzoate), as an agricultural antibiotic with high efficiency, low toxicity and low residue, has achieved large-scale production and mature technology.

[0008] Synthesize dimers, trimers and polymers of different structures of emamectin (structural formula 1).

[0009]

[0010] Structural Formula 1

[0011] The target organisms of the corresponding compounds of the parent emamectin were used as the main pests to be tested, and the screening range was appropriately expanded. The relationship between different clustering structures, different clustering degrees and biological activity was studied, and the results showed that the activity of the clusters was signifi...

Embodiment 2

[0012] Example 2: The pyrrole insecticide fipronil was used as a precursor to synthesize its dimer (structural formula 2).

[0013]

[0014] Structural formula 2

[0015] The target organisms of the corresponding compounds of parent fipronil were used as the main pests to be tested, and the screening scope was appropriately expanded. The relationship between the parent compound, the dimer and the biological activity was tested, and the results showed that the activity of the dimer was significantly higher than that of the corresponding parent compound.

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Abstract

The present invention relates to a method for developing new pesticide by utilizing cluster effect. Said invention is characterized by that it utilizes existent high-activity pesticide compounds, such as emamectin benzoate, pyrroles pesticide, new nicotine pesticide or potential pesticide active molecule as mother body to synthesize its cluster compound, and utilizes said cluster compound to develop high-effective low-toxic new pesticide.

Description

technical field [0001] The invention relates to a method for creating and discovering new pesticides, which is a method for creating new pesticides by using the principle of cluster effect. Background technique [0002] The discovery and development of new pesticide molecules is the lifeblood of the pesticide industry. There are many ways to create and research new pesticides, such as direct extraction from organisms, discovery of lead structures, and chemical modification of molecular structures of existing active ingredients. However, the creation of a new type of pesticide, from the original basic research to the industrialization, requires the full investment of strong financial and material resources and innovative scientific and technological personnel, which consumes a lot of manpower and material resources and takes a long time. Although our country has made great achievements in the development and production of pesticides, there are very few products with market e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N43/56
Inventor 宁君梅向东衣悦涛
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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