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Medicinal composition, preparation method and quality control method

A composition and drug technology, applied in the directions of drug combination, testing drug preparation, drug formula, etc., can solve the problems of low bioavailability, slow solidification effect, poor quality controllability, etc. Ischemic myocardium, easy to use and carry

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Among the causes of human death, about 17 million people die from cardiovascular and cerebrovascular diseases in the world every year, accounting for more than 50% of the total death toll, ranking first; among human diseases, the recurrence rate of cardiovascular and cerebrovascular diseases is as high as 87% , ranking first; in human diseases, the disability rate of cardiovascular and cerebrovascular diseases is as high as 50%, ranking first. This grim fact has been highly concerned by all walks of life. There are already a lot of western medicines. Chemical medicines are used to control symptoms and have definite curative effects. The scope of application is narrow, which brings disadvantages to clinicians and some patients. Although oral preparations of traditional Chinese medicine promote blood circulation and remove blood stasis, nourish both qi and blood, and treat both symptoms and root causes, there are various varieties and large options, but the bioavailability is low, so it cannot be treated quickly Cardiovascular and cerebrovascular emergencies and severe diseases, the effect of consolidating the root is more slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: prepare Rhizoma Chuanxiong extract: get 10 parts of Rhizoma Chuanxiong (part is: kilogram or gram)

[0023] Take Ligusticum chuanxiong, crush it into a coarse powder, soak it in 80% ethanol for 1 hour, then reflux extraction twice, add 8 times the amount of ethanol for the first time, extract for 2 hours, add 6 times the amount of ethanol for the second time, extract for 1.5 hours, and extract together After the extract was filtered and concentrated, it flowed through a macroporous adsorption resin column, washed with water, and then eluted with 30% ethanol. The 30% ethanol eluate was collected and concentrated under reduced pressure to obtain the Rhizoma Chuanxiong extract.

Embodiment 2

[0024] Embodiment 2: prepare Rhizoma Chuanxiong extract: 1000 parts of Rhizoma Chuanxiong (part is: kilogram or gram)

[0025] Take Ligusticum chuanxiong, crush it into a coarse powder, add water to extract 3 times, each time 10 times the amount of water, 1.5h, filter the extract, combine and concentrate the filtrate into a thick paste, add appropriate amount of water, heat to dissolve, add to the processed macropore Resin column (the ratio of dry paste and resin is 1:15-20), wash with water until the reaction of sugar is negative (1ml eluent, add 2-3 drops of 5% a-naphthol ethanol solution, shake well, Slowly add 0.5ml of concentrated sulfuric acid to the wall of the test tube, and a purple ring will form at the interface between the test solution and sulfuric acid) and elute with 30% ethanol until it is colorless, collect the eluate and recover it under reduced pressure, and dry it at low temperature (50°C) to obtain Ligusticum chuanxiong. Extract I, add 6 times the amount o...

Embodiment 3

[0026] Embodiment 3: prepare Rhizoma Chuanxiong extract: 3000 parts of Rhizoma Chuanxiong (part is: kilogram or gram)

[0027] Take Ligusticum chuanxiong, crush it into a coarse powder, extract with ethanol reflux, concentrate the extract under reduced pressure, let it cool, remove sugar and oil, remove residual ethanol in a water bath, heat water to dissolve, extract with ether after cooling, and extract the ether extract with hydrochloric acid. The acid solution was adjusted to pH 9-10 with saturated sodium carbonate, extracted with chloroform, and the chloroform was recovered under reduced pressure to obtain the chloroform extract. Dissolve the chloroform extract with hydrochloric acid, adjust the pH to about 10 with ammonia water, extract with chloroform, recover the chloroform under reduced pressure to obtain the Rhizoma Chuanxiong extract.

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from Chuan-xiong rhizonme or its extract and ozagrel. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as a preparation method and a quality control method of the composition, belonging to the technical field of medicines. technical background [0002] Among the causes of human death, about 17 million people die from cardiovascular and cerebrovascular diseases in the world every year, accounting for more than 50% of the total death toll, ranking first; among human diseases, the recurrence rate of cardiovascular and cerebrovascular diseases is as high as 87% , ranking first; in human diseases, the disability rate of cardiovascular and cerebrovascular diseases is as high as 50%, ranking first. This grim fact has been highly concerned by all walks of life. There are already a lot of western medicines. Chemical medicines are used to control symptoms and have definite curative effects. The scope of application is narrow, which brings disadva...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61K9/00A61P9/10A61P7/02G01N33/15A61K31/4164
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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