7 alpha-substituted 11 alpha-hydroxysteroids and its microbiological production method

A technique of steroids and pharmacology, applied in the field of 7α-substituted 11α-hydroxy steroids and their microbiological preparation
CN1923841AInactive Publication Date: 2007-03-07SCHERING AG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SCHERING AG
Publication Date
2007-03-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed is a new synthetic pathway for the production of precursors for the production of compounds having general formula (8,10,12). During said synthesis, compounds of general formal (4,B) are produced in a microbiological reaction. The meanings of radicals R<7>, R<10>, R<11>, R<13>, R<17> and R<17'> and group U-V-W-X-Y-Z are defined in the patent claims.
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Description

[0001] This application is a divisional application of the invention patent application No. 03817696.3 (PCT / EP2003 / 008111) entitled "Microbiological method for preparing 7α-substituted 11α-hydroxy steroids" filed on July 24, 2003. technical field

[0002] The present invention relates to a microbial process for the preparation of 7α-substituted 11α-hydroxy steroids and to 7α,17α-substituted 11β-halogen steroids which can be prepared therefrom, to a process for the preparation of the latter compounds and to their use as well as to compounds comprising these pharmaceutical preparations. Furthermore, the present invention relates to other 7α-substituted 11β-halogen steroids, namely 7α-substituted estro-1,3,5(10)-tri alkene. Background technique

[0003] Androgens, especially testosterone, are used to treat andropause symptoms and for male genital development and male birth control. In addition, these hormones also have some anabolic active ingredients that promote, for exampl...

Claims

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