Slow released indapamide microcapsule and its prepn process

A technology for indapamide pellets and sustained-release pellets, which is applied in the field of indapamide sustained-release pellet capsules and its preparation, can solve the problems of poor process repeatability, inability to ensure sustained-release performance, complicated processes, etc. Ensuring the effect of timed and quantitative release

Inactive Publication Date: 2007-03-21
珠海天翼医药技术开发有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this method needs to take out the micropill of different coating amounts in the coating process, measure the release rate and content of the micropill of coating weight gain, mix in proportion after calculation, measure release rate and content again, this not only makes process It ...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] 1000 Indapamide Sustained-Release Micropellet Capsules,

[0010] Indapamide 1.5g

[0011] Blank pill core 180.0g

[0012] Povidone 7.5g

[0013] Acrylic resin (RS) 20.0g

[0014] Dibutyl Sebacate 2.0g

[0015] Talc 10.0g

[0016] Magnesium Stearate 1.0g

[0017] Place the commercially available hollow pellet cores between 25 / 30 mesh in a coating machine, spray a povidone solution containing indapamide to make drug-containing pellets; dissolve acrylic resin retardation with an appropriate amount of 95% ethanol. The release material EUDRAGITRS100 was added, and the coating auxiliary materials such as talc and magnesium stearate were added to an appropriate amount of 95% ethanol, and stirred to prepare a slow-release coating solution; then on the drug-containing pellets, the prepared slow-release coating was sprayed evenly. Coating with the release coating liquid until all the slow-release coating liquid was sprayed to make slow-release pellets; place the slow-releas...

Embodiment 2

[0019] 1000 capsules called dapamide extended-release capsules

[0020] Indapamide 1.5g

[0021] Blank pill core 195.0g

[0022] Povidone 4.5g

[0023] Acrylic resin (RS) 15.0g

[0024] Polyethylene glycol 6000 1.5g

[0025] Talc 8.0g

[0026] Magnesium Stearate 1.0g

[0027] Place the commercially available hollow pellet cores between 25 / 30 mesh in a coating machine, spray a povidone solution containing indapamide to make drug-containing pellets; dissolve acrylic resin retardation with an appropriate amount of 95% ethanol. The release material EUDRAGITRS100 was added, and the coating auxiliary materials such as talc and magnesium stearate were added to an appropriate amount of 95% ethanol, and stirred to prepare a slow-release coating solution; then on the drug-containing pellets, the prepared slow-release coating was sprayed evenly. Coating with the release coating liquid until all the slow-release coating liquid was sprayed to make slow-release pellets; place the slow...

Embodiment 3

[0029] 1000 capsules called dapamide extended-release capsules

[0030] Indapamide 1.5g

[0031] Blank pill core 170.0g

[0032] Povidone 15.0g

[0033] Acrylic resin (RS) 15.0g

[0034] Polyethylene glycol 6000 1.5g

[0035] Talc 6.0g

[0036] Magnesium Stearate 1.0g

[0037]Place the commercially available hollow ball cores between 25 / 30 mesh in a coating machine, spray the povidone solution containing indapamide to make drug-containing pellets; Release material EUDRAGITRS100, and at the same time, add coating auxiliary materials such as talc powder and magnesium stearate to an appropriate amount of 95% ethanol, stir to prepare a sustained-release coating solution; then spray the prepared slow-release coating solution evenly on the drug-containing pellets. release coating liquid for coating until spraying all the sustained-release coating liquid to make sustained-release pellets; place the sustained-release pellets in a 60°C drying oven to dry for 2 hours, measure the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to view more

Abstract

The present invention is one kind of slow released capsule with slow released indapamide microcapsule as main component and homogeneous medicine release. The slow released microcapsule includes medicine microcapsule with indapamide as active component and slow releasing coating layer around the medicine microcapsule. The supplementary material includes supplementary material to constitute the medicine microcapsule together with indapamide and the slow releasing material. In the slow released microcapsule, the weight ratio of indapamide, the supplementary material and the slow releasing material is 0.5-3.0 to 1-10 to 165-400. The slow released microcapsule is prepared through a coating process. The slow released preparation of the present invention has prolonged in vivo residence time of the medicine, controlled medicine release, lowered toxic side effect and raised curative effect.

Description

technical field [0001] The invention relates to the field of medicines and preparations thereof, in particular to an indapamide sustained-release pellet capsule capable of treating hypertension and a preparation method thereof. technical background [0002] Hypertension is a common and frequently-occurring disease with a high morbidity rate. If the treatment is not properly treated or not treated in time, it may lead to serious complications that endanger the physical and mental health of patients, and even endanger their lives. Indapamide is a new type of sulfonamide diuretic. It is mainly used for the treatment of hypertension. It has diuretic, calcium antagonistic, antioxidant and free radical elimination properties, and can stimulate the synthesis and inhibition of prostaglandins with free vasodilator effects. Pharmacological effects such as vasoconstriction. [0003] In the prior art, indapamide is mainly a daily 2.5mg oral immediate-release dosage form and a daily 1.5...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/404A61K9/50A61P9/12
Inventor 张晓明
Owner 珠海天翼医药技术开发有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap