Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Huangyangning alkaloid and analogue acidic amino acid double salts or composition for treating cardio-cerebrovascular diseases

A technique for cardiovascular and cerebrovascular diseases and acidic amino acids, which is applied in the field of acid amino acid double salts or compositions of boxwood and analogs for the treatment of cardiovascular and cerebrovascular diseases, can solve the problems that the curative effect of spontaneous angina pectoris needs further observation and the like, and achieves The effect of solving instability and water insolubility, improving clinical efficiency, and broadening the route of administration

Inactive Publication Date: 2007-03-28
SICHUAN GUOKANG PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. Treatment of angina pectoris Huang Yangning treated 72 cases of angina pectoris, the total effective rate was 80.5%, and the curative effect on stable fatigue angina pectoris was better (total effective rate 82.6%), and the curative effect on spontaneous angina pectoris needs further observation
There are no reports of double salts of acidic amino acids such as glutamic acid and aspartic acid

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Huangyangning alkaloid and analogue acidic amino acid double salts or composition for treating cardio-cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, the preparation of Huowei Huang Yangxing D glutamic acid double salt

[0020] Weigh 20mg of Huanwei Huangyangxing D4, completely dissolve in 60ml of absolute ethanol at low temperature, under nitrogen protection, feed in batches under full stirring, and add 268mg of L-glutamic acid. Let it cool down slightly, add sodium carbonate solution dropwise under stirring, and monitor the pH change until the pH is about 7-8. Continue to stir and reflux for 3 to 4 hours. After the reaction is completed, the reaction solvent is removed by rotary evaporation. After the residue is vacuum-dried for 2 hours, add 60ml to 100ml of ethanol, shake fully, filter under reduced pressure, and recover ethanol from the filtrate under reduced pressure. Place, filter with suction, and combine the filtrates. The filtrate was ultrasonically treated for 15-30 minutes, and then filtered with a 0.22 μm microporous membrane, and the filtrate was distilled to volume to obtain the final pr...

Embodiment 2

[0021] Example 2, Preparation of Huanwei Huangyangxing D Aspartic Acid Double Saline Injection

[0022] Weigh 150g of Huanwei Huangyangxing D aspartic acid double salt, add 20,000ml of purified water for injection, dissolve, filter, prepare 2ml / bottle, and sterilize to obtain 10,000 water injections. Each tube contains 15mg of cyclovir baxangate D aspartic acid double salt.

Embodiment 3

[0023] Example 3, Preparation of Huanwei Huangyangxing D Glutamic Acid Powder Injection

[0024] Weigh 200g of huanweihuangyangxing D glutamic acid double salt, dextran S 40 160g, add 25000ml of water for injection to dissolve, filter through a 0.22μm microporous membrane, measure the content, and pack into 2.5ml each. Freeze-dry to obtain 10,000 vials of Huowei Huang Yang Xing D glutamic acid double salt powder injection, each containing 20 mg of Huo Wei Huang Yang Xing D glutamate double salt.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to an acid amino acid double salt or composition medicine of buxenine and analogues for curing angiocardiopathy and cerebrovascular disease. The described medicine composition includes (by weight portion) 1 portion of buxenine (and its analogues) and 0.01-100 portions of G (G is alkaline amino acid, namely one of glutamic acid and asparagic acid, etc. or their mixture), and the rest is medicinal auxiliary material. Said medicine composition can be made into various dosage forms of powder injection, liquor injection, oral solution, capsule, tablet, dripping pill and others.

Description

technical field [0001] The present invention relates to the acidic amino acid double salt of buxangine and its analogues (such as cyclovir buxaxacin D, etc.) or its composition medicine for treating cardiovascular and cerebrovascular diseases in the technical field of medicine, specifically composed of buffaline (and its Analogue) 1 part, G0.01~100 parts [G is an acidic amino acid, that is, one of glutamic acid, aspartic acid, etc. (organic acids with more carboxyl groups than amino groups in the molecular structure) or any of them Several combinations in any proportion], and the rest are pharmaceutical excipients, compound salts formed by compatibility or combination drugs. Background technique [0002] Cardiovascular and cerebrovascular disease is the disease with the highest mortality rate in the world today, killing more than 120 million people every year, accounting for more than 25% of the global death total, and disabling thousands of patients. Moreover, the age tend...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K9/00A61P9/00
Inventor 支春周旋吴成龙江雪
Owner SICHUAN GUOKANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com