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Danshen root drop pills for treating coronary heart disease and preparation thereof

A technology of coronary heart salvia miltiorrhiza and tablet dripping pills, which is applied in the field of therapeutic drugs and its preparation, can solve problems such as delaying blood stoppage, and achieve the effects of improving bioavailability, accurate drug dosage, and light weight

Inactive Publication Date: 2007-04-04
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Effects on the cardiovascular system: Experiments have shown that single flavor Jiangxiang can significantly promote the recovery of blood flow in the experimental mesenteric microcirculation of mice, as well as the recovery of arterioles after contraction and the recovery of local microcirculation. The constriction effect of arterioles is strong, but the effect of delaying blood cessation is weak

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1-Guanxin Danshen Tablets dripping pills (1)

[0038] Method: take 0.1 g of polyethylene glycol 2000, 13 g of polyethylene glycol 4000, 23.5 g of polyethylene glycol 6000, 0.1 g of polyethylene glycol 8000, 0.1 g of polyethylene glycol 10000, polyoxyl stearate 40 Ester 1g, Beta Cyclodextrin 0.5g, Poloxamer 0.5g, Carboxymethyl Starch Sodium 0.5g, Stearic Acid 0.1g, Sodium Stearate 0.1g, Glycerin Gelatin 0.1g, Monostearic Acid Glyceride 0.1 g, shellac 0.1 g, polyoxyethylene monostearate 0.1 g, polyether 0.1 g, mix well, then add salvia miltiorrhiza, Panax notoginseng, balsamic oil extract raw materials 10 g, fully stir and mix evenly, use Heat the prepared mixture of raw and auxiliary materials to a molten state by means of electric heating, and use a self-made special dropping pill machine to adjust the dripper temperature and keep it at 85°C (error <2%); methyl silicone oil is used as a condensing agent , adjust the refrigeration control s...

Embodiment 2

[0040] The preparation of embodiment 2-Guanxin Danshen Tablets dripping pills (2)

[0041] Method: Take 10 grams of polyethylene glycol 4000, 20 grams of polyethylene glycol 6000, 3 grams of polyoxyl 40 stearate, 6 grams of beta cyclodextrin, and 1 gram of glyceryl monostearate, and mix well , then add 10 grams of salvia miltiorrhiza, Panax notoginseng, and balsamic oil extract raw materials, fully stir and mix evenly, use electric heating to heat the prepared raw and auxiliary material mixture to a molten state, and use a self-made special dropping pill machine to adjust the dripper temperature and keep it at 85°C (error<2%); take methyl silicone oil as the condensing agent, adjust the refrigeration control system of the dropping pill machine to keep the temperature of the condensing agent at 20→-5°C (error<5%), Carry out dripping again according to the method given by the previous preparation process, take out after shrinkage molding, remove the surface condensing agent, dry...

Embodiment 3

[0043] The preparation of embodiment 3-Guanxin Danshen Tablets dripping pills (3)

[0044] Method: Take 11 grams of polyethylene glycol 4000 and 29 grams of polyethylene glycol 6000, mix well, then add 10 grams of salvia miltiorrhiza, Panax notoginseng, and balsamic oil extracts, stir and mix well, and heat the prepared A good mixture of raw and auxiliary materials is heated to a molten state, and a self-made special pilling machine is used to adjust the temperature of the dripper and keep it at 85°C (error <2%); using methyl silicone oil as a condensing agent, adjust the temperature of the dripping machine. The refrigeration control system keeps the temperature of the condensing agent at 20→-5°C (error <5%), and then drips according to the method given in the previous preparation process. After shrinking and molding, take it out, remove the surface condensing agent, dry, and make Be into the drop pill of pill weight 50mg containing medicine 10mg / grain, then carry out the men...

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Abstract

A dripping pill of red sage root, notoginseng and dalbergia wood is prepared from red sage root, notoginseng and dalbergia wood through proportional adding polyoxyvinyl monostearate, mixing, heating for fusing, stirring, and dripping in condensing liquid.

Description

[0001] [Technical field] The present invention relates to a kind of therapeutic medicine and preparation method thereof, particularly Guanxin Danshen tablet dripping pill and preparation method thereof. [Background technique] [0002] Dropping pills refer to preparations made by heating, melting and mixing solid or liquid medicines and substrates, then dropping them into immiscible condensate, and condensation and shrinkage. Because the drug is dispersed in extremely fine particles, colloidally dispersed in the solution, and becomes a rapidly dissolving amorphous mixture, it can effectively improve the oral bioavailability of the drug. In 1971, the rue oil dripping pills that went on the market in my country made the dripping pills truly an effective medicinal dosage form. Dropping pills can be used internally, externally and locally, and can also be made into sustained-release preparations. They have played and continue to play an important role in the field of pharmaceutical...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61K47/14A61K47/34A61K47/36A61K47/40A61K47/42A61P9/10A61K47/10
Inventor 刘凤鸣
Owner 刘凤鸣
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