Medicine composition for treating neurosis

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for the treatment of neurosis, can solve the problems of narrow application range and single effect in clinical application, and achieve the effects of less adverse reactions, good therapeutic effect and low recurrence rate

Inactive Publication Date: 2007-06-27
刘超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the scope of adaptation is relatively narrow, and the traditional Chinese medicine prescription with single effect can not meet the needs of clinical application far away.

Method used

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  • Medicine composition for treating neurosis

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Effect test

Embodiment 1

[0038] Example 1: Experiment of the drug of the present invention against the eyelid drooping caused by reserpine in mice

[0039] experimental method

[0040] The Pharmacology Department of Basic Medical College of Hebei Medical University used 40 Kunming mice, half male and half male, and randomly divided into a blank control group, a positive drug control group, an experimental group 1 and an experimental group 2, a total of 4 groups. Each of the above groups was given liquid with a volume of 0.2ml / 10g body weight by gavage, the blank control group was fed only water; the positive drug control group was intraperitoneally injected with imipramine 25mg / kg, and the experimental group was given the powder of the present invention at 1.0g / kg, Gavage 2.0g / kg (divided into experimental group 1 and experimental group 2) for 7 days; 1 hour before the last dose, observe whether there is ptosis, and then immediately inject reserpine 0.5 mg / kg subcutaneously , 5 hours later, the degree of ...

Embodiment 2

[0048] Example 2: The effect of the drug of the present invention on prolonging the sleep time of mice induced by pentobarbital sodium

[0049] experimental method

[0050] Fifty Kunming mice, half male and half male, were randomly divided into 5 groups: blank control group, positive control group, and experimental group. Each of the above groups was given liquid with a volume of 0.2ml / 10g body weight by gavage, the blank control group was fed only water, the positive control group was given intraperitoneal injection of imipramine 25mg / kg, and the experimental group was given the powder of the present invention at 0.5g / kg, 1.0g / kg, 2.0g / kg gavage (divided into three groups of experimental group 1, experimental group 2, and experimental group 3) for 3 days; 30 minutes after the last administration, sodium pentobarbital 50mg / kg Intraperitoneal injection, taking the disappearance of the righting reaction as a sleep indicator, observe the effect of each group on prolonging the sleep t...

Embodiment 3

[0055] Example 3: Acute toxicity experiment of the drug of the present invention.

[0056] experimental method

[0057] Take 20 Kunming mice, weighing 18-22g, half male and half, take 30g of the medicine powder of the present invention, add water to 75mL, grind to prepare a 40% suspension, give 0.4ml / 10g body weight and give a total of 3 Times, the administration interval is 2 hours. After the first administration, the mice foraging, drinking, and activities were normal; after the second administration, the mice squatted with their eyes closed and their response to stimuli decreased. 1.5 hours after the administration, loose stools appeared on 9 / 20. After the third administration, the mice appeared lethargic and all had loose stools about 1 hour after the administration. The activities and behaviors of all mice returned to normal on the second day after administration. A total of 7 days of observation, no death occurred. The male mice weighed 21.4±1.1g before the experiment and 24...

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Abstract

The present invention discloses a kind of neurosis treating medicine composition, which is prepared bupleurum root, kudzu vine root, corydalis tuber, white peony root, cassia twig and other nine kinds of Chinese medicinal materials in certain weight proportion. The medicine composition may be used in preparing different preparations for treating different types of neurosis, and has high curative effect and fast acting. The present invention is suitable for industrial production.

Description

Technical field [0001] The invention relates to a medical preparation, in particular to a pharmaceutical composition particularly suitable for the treatment of neurosis. technical background [0002] Neurosis is a common disease. It is usually a series of mental, neurological and physical symptoms caused by temporary dysfunction of brain activity caused by the interaction of various factors such as personality, psychology, and society. During clinical examination, No corresponding pathological signs were found. The course of neurosis is protracted, and the incidence is increasing year by year. The World Health Organization estimates based on survey data from various countries that the incidence of neurosis in the population is about 5% to 8%. The incidence in western developed countries is generally 10% to 20%. Neurosis is generally prevalent in the Chinese population, and its incidence should be higher than in western developed countries. Clinically, the common types of neurosis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P25/00A61P25/20A61P25/22A61P25/24A61K35/56A61K35/618
Inventor 刘超刘坤申
Owner 刘超
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