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Methods and kits for use in preventing restenosis

a technology of restnosis and kits, applied in the field of vascular disease, can solve the problems of incomplete understanding of restnosis, remodeling and narrowing of the vessel, and no particular technique has yet emerged as completely satisfactory

Inactive Publication Date: 2001-08-23
CORDIS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While it is known that restenosis is not caused by blood clots forming at the widened site, the cause of restenosis is not completely understood.
Instead, restenosis results from scarring, which results in a remodeling and narrowing of the vessel.
While a variety of different protocols are currently being tested for their effectiveness and safety in the prevention of restenosis (some of which have been described above), no particular technique has yet emerged as completely satisfactory.

Method used

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  • Methods and kits for use in preventing restenosis
  • Methods and kits for use in preventing restenosis
  • Methods and kits for use in preventing restenosis

Examples

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Embodiment Construction

[0017] Methods are provided for use in the prevention of restenosis. In the subject methods, a vascular site of a host is contacted, e.g. flushed, with a solution having a subphysiologic pH, e.g. a solution having a pH of less than about 4. The vascular site is contacted with the solution of reduced pH for a period of time sufficient for at least the progression of restenosis at the vascular site to at least be slowed, if not prevented. The subject methods may be used in conjunction with other restenosis prevention protocols, e.g. stenting. Also provided are kits for use in practicing the subject methods. In further describing the subject invention, the subject methods are reviewed first in greater detail, followed by a discussion of the subject kits and components thereof for practicing the subject methods.

[0018] Before the subject invention is described further, it is to be understood that the invention is not limited to the particular embodiments of the invention described below,...

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PUM

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Abstract

Kits and methods for their use are provided for at least inhibiting the progression of, if not preventing, restenosis in a host. In the subject methods, a vascular site is contacted, usually flushed, with a solution having a pH that is less than about 4, e.g. a hydrochloric acid. The subject kits methods find use in applications where the prevention of restenosis is desirable, including angioplasty applications, and may be used in combination with other treatment modalities, e.g. stents, and the like.

Description

[0001] This application is a continuation-in-part of application Ser. No. 09 / 454,235 filed on Dec. 2, 1999 and issued as U.S. Pat. No. 6,156,350 on Dec. 5, 2000; the disclosure of which is herein incorporated by reference.[0002] 1. Technical Field[0003] The field of this invention is vascular disease, particularly restenosis and the prevention or treatment thereof.[0004] 2. Background of the Invention[0005] "Restenosis" refers to the renewed narrowing of an artery, e.g. a coronary artery, following a vessel opening or widening procedure, such as angioplasty or atherectomy. In restenosis, a vessel that has been treated to at least minimize the volume of a lesion or blockage and thereby restore blood flow, e.g. by balloon angioplasty, starts to renarrow, typically within about six months of the vessel widening procedure. This renarrowing often requires additional treatment, such as additional angioplasty procedures. It has been estimated that as much as one third to one half of all an...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K33/00A61K33/14A61K33/20
CPCA61K33/00A61K33/14A61K33/20A61K2300/00A61P9/00
Inventor CONSTANTZ, BRENT R.
Owner CORDIS CORP