Compounds which inhibit HIV replication

Abstract

This invention relates to human immunodeficiency virus (HIV) protein fragments which have antiviral activity, and particularly relates to HIV peptides derived from the HIV transmembrane glycoprotein (gp41) which inhibit HIV-induced cell-cell fusion. This invention further relates to methods for the inhibition of enveloped viral infection, and to methods that modulate biochemical processes which involve coiled coil peptide interactions.

Description

[0001] This application-is a continuation-in-part of co-pending application Ser. No. 07 / 927,532 of C. Wild, T. Matthews and D. Bolognesi, filed Aug. 7, 1992, the disclosure of which is to be incorporated by reference herein in its entirety.1. INTRODUCTION[0003] This invention relates to human immunodeficiency virus (HIV) protein fragments which have antiviral activity, and particularly relates to HIV peptides derived from the HIV transmembrane glycoprotein (gp41) which inhibit HIV-induced cell-cell fusion. This invention further relates to methods for the inhibition of enveloped viral infection, and to methods that modulate biochemical processes which involve coiled coil peptide interactions.2. BACKGROUND OF THE INVENTION[0004] Numerous HIV protein fragments, or peptides, have been identified in an effort to develop an effective HIV vaccine. See generally B. Spalding, Biotechnology 10, 24 (Jan. 1992). Examples of patent applications which are directed to antigenic epitopes of the gp...

AI Technical Summary

Benefits of technology

0015] (SEQ ID NO: 1); and (ii) peptides of from 14 to 60 amino acids in length which form a heterodimer with the peptide DP-107 (SEQ ID NO: 1); and then (b) detecting whether the test compound disrupts said multimer, the ability of the test compound to disrupt the multimer indicating the test compound is capable of inhibiting HIV infec

Problems solved by technology

To date, the development of an anti-HIV vaccine has been difficult.

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