Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics

a monoclonal antibody and cd23 technology, applied in the field of monoclonal antibodies, can solve the problems of ige production uncertainty, inhibited ige expression, and widespread suffering in the general population, and achieve the effect of enhancing the potential for cross-linking
US20050118175A1Inactive Publication Date: 2005-06-02BIOGEN IDEC MA INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BIOGEN IDEC MA INC
Publication Date
2005-06-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods for inhibiting IgE production in a human subject using anti-CD23 antibodies.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to monoclonal antibodies containing human gamma-1 constant domains which specifically bind human CD23, the low affinity receptor for IgE (FceRII / CD23) and their usage as therapeutic agents. BACKGROUND OF THE INVENTION

[0002] IgE is a member of the immunoglobulin family that mediates allergic responses such as asthma, food allergies, type 1 hypersensitivity and the familiar sinus inflammation allergic rhinitis and conjunctivitis, and as a result, causes widespread suffering throughout the general population. IgE is secreted by, and expressed on the surface of, B-cells. IgE synthesized by B-cells can be anchored in the B-cell membrane by a short transmembrane domain linked to the mature IgE sequence. Membrane and secreted versions of IgE are formed in the same cell by differential splicing of the IgE RNA transcript.

[0003] IgE also can be bound to B-cells (and T cells, monocytes, Langerhans cells, follicular dendritic cells, ...

Claims

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