Coating compositions for bioactive agents

a bioactive agent and coating composition technology, applied in the field of coating compositions for bioactive agents, can solve the problems of ischemic injury, stroke or myocardial infarction, sudden closure of the vessel, and numerous physiological complications

Inactive Publication Date: 2005-10-06
SURMODICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015] In turn, compositions of the present invention provide properties that are comparable or better than those obtained with previous polymer blend compositions. This, in turn, provides a variety of new and further opportunities, including with respect to both the type and concentration of bioa

Problems solved by technology

Many individuals suffer from circulatory disease caused by a progressive blockage of the blood vessels, which often leads to hypertension, ischemic injury, stroke, or myocardial infarction.
A limitation associated with PTCA is the abrupt closure of the vessel which can occur soon after angioplasty.
. . ), after placement in the body, can give rise to numerous physiological complications.
Some of these complications include: increased risk of infection; initiation of a foreign body response resulting in inflammation and fibrous encapsulation; and initiation of a detrimental wound healing response resulting in hyperplasia and restenosis.
These problems have been particularly acute with the placement of stents in damaged arteries after angioplasty.
Although the potential bene

Method used

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  • Coating compositions for bioactive agents
  • Coating compositions for bioactive agents
  • Coating compositions for bioactive agents

Examples

Experimental program
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Effect test

example 1

Release of Rapamycin from Poly(styrene-co-butadiene) and Poly(butyl methacrylate)

[0120] Three solutions were prepared for coating the stents. The solutions included mixtures of poly(styrene-co-butadiene) copolymer (“SBR”, available from Scientific Polymer Products, Inc. Catalog #100, contains 23% (wt) styrene), poly(butyl methacrylate) (“PBMA”, available from Sigma-Aldrich Fine Chemicals as Product No. 18,152-8, having a weight average molecular weight (Mw) of about 337 kilodaltons), and rapamycin (“RAPA”, available from LC Laboratories, Woburn, Mass.) dissolved in THF to form a homogeneous solution. The stents were not given a primer pre-treatment.

[0121] The solutions were prepared to include the following ingredients at the stated weights per milliliter of THF: [0122] 1) 16 mg / ml SBR / 4 mg / ml PBMA / 10 mg / ml RAPA [0123] 2) 10 mg / ml SBR / 10 mg / ml PBMA / 10 mg / ml RAPA [0124] 3) 4 mg / ml SBR / 16 mg / ml PBMA / 10 mg / ml RAPA

[0125] Using the Sample Preparation Procedure, two stents were spray ...

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Abstract

A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.

Description

RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application Ser. No. 60 / 559,821, titled Coating Compositions for Bioactive Agents, filed Apr. 6, 2004, the contents of which are hereby incorporated by reference. This application is related to PCT Application Ser. No._______, filed Apr. 6, 2005, titled Coating Compositions for Bioactive Agents and identified by Attorney Docket No. 9896.166.7, as well as PCT Application Ser. No._______ filed Apr. 6, 2005, titled Coating Compositions for Bioactive Agents and identified by Attorney Docket No. 9896.166.8, the contents of both of which are hereby incorporated by reference.TECHNICAL FIELD [0002] In one aspect, the present invention relates to a method of treating implantable medical devices with coating compositions to provide for the controlled release of bioactive (e.g., pharmaceutical) agents from the surface of the devices under physiological conditions. In another aspect, the invention relates to the...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61F2/86A61K9/14A61L29/08A61L29/16A61L31/10A61L31/16
CPCA61F2/86A61F2250/0067A61L29/085A61L29/16A61L31/10A61L31/16A61L2300/222A61L2300/404A61L2300/41A61L2300/416A61L2300/42A61L2300/43A61L2300/602A61L2300/606C08L33/06C08L33/10C08L71/02
Inventor DEWITT, DAVID M.FINLEY, MICHAEL J.LAWIN, LAURIE R.
Owner SURMODICS INC
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