Network models of biochemical pathways

Abstract

This invention describes computer based systems and methods for modeling and simulation of biochemical networks of pathways, including metabolic, signal transduction and regulatory pathways within a cell or across cells. The invention comprises systems and methods for building the models and for using the models for analysis and information retrieval, for determining the effect that modulating one or more reactions in a biochemical pathway has on an operation of the biochemical pathway, and for simulating or predicting an altered physiological state of cells.

Description

PRIORITY CLAIMED

[0001] This is a divisional application of pending U.S. Ser. No. 08 / 860,975, filed on Dec. 22, 1997, which is a national stage filing under 35 CFR § 371 of International Application No. PCT / US96 / 00883, filed on Jan. 17, 1996, which was published in English under PCT Article 21(2) as WO 96 / 22575, and which claims the benefit as a continuation-in-part of the combined U.S. application Ser. Nos. 08 / 373,688 and 08 / 373,992, both filed Jan. 17, 1995. U.S. Ser. No. 08 / 373,688, now abandoned, was continued as Ser. No. 08 / 889,624, filed Jul. 8, 1997, and issued as patent U.S. Pat. No. 5,930,154 on Jul. 27, 1999. U.S. Ser. No. 08 / 373,992 issued as patent U.S. Pat. No. 5,980,096, on Nov. 9, 1999. Related patent EP 0821817, entitled “Control Systems Based on Simulated Virtual Models”, was granted on Jun. 23, 1999. The specifications, drawings and appendixes of each of the above-referenced patent applications are incorporated herein by reference.COMPACT DISC APPENDIX

[0002] The T...

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