Compounds, formulations, and methods for treating or preventing inflammatory skin disorders

Abstract

In methods, compounds, and topical formulations for treatment of inflammatory skin disorders incorporating compounds represented by the formulas below: wherein each of R1, R2, and R3 is independently hydrogen, hologen, alkyl, or alkoxy; each of R4 and R5 is independently hydrogen, alkyl, or alkoxy; and each of R6 and R7 is independently hydrogen, nitro, alkyl, or alkoxy; wherein each of A1, A3, and A4 is independently hydrogen or alkyl; and A2 is independently hydrogen or hydroxy; and wherein each of B1, B2, and B3 is independently hydrogen, hydroxy, or alkoxy; and each of B4 and B5 is independently hydrogen or alkyl, applying such compounds topically as sprays, mists, aerosols, solutions, lotions, gels, creams, ointments, pastes, unguents, emulsions, and suspensions to treat inflammatory skin disorders and the symptoms associated therewith.

Description

CROSS REFERENCE TO RELATED APPLICATION [0001] This application claims priority to U.S. Patent Application Ser. No. 60 / 574,142, filed May 25, 2004, which is incorporated herein by reference. This application is also a divisional of U.S. patent application Ser. No. 10 / 853,585, filed May 25, 2004, which in turn claims priority from U.S. Patent Application Ser. No. 60 / 473,611, filed on May 27, 2003, both of which are incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention is directed to compounds and methods for treatment or prevention of inflammatory skin disorders. The compounds and methods taught by the present invention are particularly useful for treating or preventing inflammatory skin disorders and the symptoms associated therewith. BACKGROUND OF THE INVENTION [0003] Many people are affected by inflammatory skin disorders that result in unsightly and painful rashes, acne, persistent red veins, and acne-like skin eruptions, such as macules, nodules, an...

AI Technical Summary

Benefits of technology

"The present invention provides methods, compounds, and topical skin formulations for the treatment of inflammatory skin disorders, such as rosacea, and their symptoms. The compounds are α2 adrenoceptor agonists that act on the peripheral vasculature to cause vasoconstriction and alleviate the symptoms of inflammatory skin disorders. The compounds are delivered in a topical skin composition that ensures they are effective in the skin of a patient without causing serious systemic side effects. The compounds can be represented by formulas I, II, and III, and formulations for their topical delivery are well-known in the art. The technical effects of the invention are improved treatment and prevention of inflammatory skin disorders."

Problems solved by technology

The compounds are delivered in a topical skin composition that insures that the compounds are effective in the skin of a patient but do not penetrate the skin in sufficient amounts to induce serious systemic side effects.

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