Compounds, formulations, and methods for treating or preventing inflammatory skin disorders
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a technology for inflammatory skin disorders and compounds, applied in the direction of biocide, drug compositions, extracellular fluid disorders, etc., can solve the problem that the amount of inflammatory skin cannot penetrate the skin in sufficient quantities to induce serious systemic side effects, and achieve the effect of improving the symptoms of rosacea, and reducing the risk of rosacea
Inactive Publication Date: 2005-12-15
GALDERMA LAB LP +1
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The compounds are delivered in a topical skin composition that insures that the compounds are effective in the skin of a patient but do not penetrate the skin in sufficient amounts to induce serious systemic side effects.
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1.1 COMPOUNDS OF THE INVENTION
[0020] In one embodiment, the invention is directed to compounds of the Formula I:
[0021] wherein each of R1, R2, and R3 is independently hydrogen, halogen, alkyl, preferably, unsubstituted alkyl, or alkoxy, preferably, unsubstituted alkoxy; each of R4 and R5 is independently hydrogen, alkyl, preferably, unsubstituted alkyl, or alkoxy, preferably, unsubstituted alkoxy; and each of R6 and R7 is independently hydrogen, nitro, alkyl, preferably, unsubstituted alkyl, or alkoxy, preferably, unsubstituted alkoxy. In a preferred embodiment of the compounds of Formula I, R6 and R7 are both hydrogen. In another preferred embodiment, R4 and R5 are both hydrogen.
[0022] In another embodiment, the invention is directed to compounds of the Formula Ia;
[0023] wherein each of R1, R2, and R3 is independently hydrogen, halogen, alkyl, preferably, unsubstituted alkyl, or alkoxy, preferably, unsubstituted alkoxy; each of R4 and R5 is independently hydrogen, alkyl, pref...
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Abstract
In methods, compounds, and topical formulations for treatment of inflammatory skin disorders incorporating compounds represented by the formulas below: wherein each of R1, R2, and R3 is independently hydrogen, hologen, alkyl, or alkoxy; each of R4 and R5 is independently hydrogen, alkyl, or alkoxy; and each of R6 and R7 is independently hydrogen, nitro, alkyl, or alkoxy; wherein each of A1, A3, and A4 is independently hydrogen or alkyl; and A2 is independently hydrogen or hydroxy; and wherein each of B1, B2, and B3 is independently hydrogen, hydroxy, or alkoxy; and each of B4 and B5 is independently hydrogen or alkyl, applying such compounds topically as sprays, mists, aerosols, solutions, lotions, gels, creams, ointments, pastes, unguents, emulsions, and suspensions to treat inflammatory skin disorders and the symptoms associated therewith.
Description
CROSS REFERENCE TO RELATED APPLICATION [0001] This application claims priority to U.S. Patent Application Ser. No. 60 / 574,142, filed May 25, 2004, which is incorporated herein by reference. This application is also a divisional of U.S. patent application Ser. No. 10 / 853,585, filed May 25, 2004, which in turn claims priority from U.S. Patent Application Ser. No. 60 / 473,611, filed on May 27, 2003, both of which are incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention is directed to compounds and methods for treatment or prevention of inflammatory skin disorders. The compounds and methods taught by the present invention are particularly useful for treating or preventing inflammatory skin disorders and the symptoms associated therewith. BACKGROUND OF THE INVENTION [0003] Many people are affected by inflammatory skin disorders that result in unsightly and painful rashes, acne, persistent red veins, and acne-like skin eruptions, such as macules, nodules, an...
Claims
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Patent Type & Authority Applications(United States)
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