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Method and pharmaceutical to treat spinal discs

a technology of spinal discs and pharmaceuticals, applied in the field of spinal disc treatment, can solve the problems of disc degeneration, disc degeneration, and further disc breakdown, and achieve the effects of reducing the number of patients, and increasing the risk of complications

Inactive Publication Date: 2005-12-22
NOTOGEN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When an intervertebral disc becomes injured, the natural reparative process is often hindered due to limited blood supply to the inner portion of the intervertebral disc.
If the normal reparative process is inadequate, the disc can continue to degenerate and be the source of pain.
The chemicals cause further breakdown of the disc and when the chemicals escape into the spinal canal inflammation occurs and effects the spinal nerves causing further pain.
This procedure is very expensive.
However pain improvement is problematical.
The latter group often becomes permanently disabled and dependent upon opioid medications.
When there is recurrence of low back pain after injury or stress the condition usually becomes more serious.
In an abnormal disc pain is provoked, and if it causes the pain that is experienced by the patient, then the disc is concordantly painful.
Successful results are modest.
These two devices have limited use.
They can only be used on intervertebral discs that have nearly normal height, have a single fissure and are chemically sensitive.

Method used

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Embodiment Construction

[0014] Observation based upon injection treatment of soft tissue injuries, namely ligaments, tendons and fascia, wherein the injected solution causes a mild inflammatory reaction followed by a reparative response within the tissues, led to the concept that painful and damaged intervertebral discs could be treated similarly. The solution selected to test this hypothesis was the combination of chondroitin sulfate, glucosamine HCl, hypertonic dextrose, bupivicaine and DMSO (dimethyl sulfoxide) when indicated. Because the solution becomes acidic with a pH of 4.3, a buffer solution has also been added to the solution, namely a combination of mono and diphosphates which increases the pH level to above about 6.0, and preferably between about 6.3 to about 6.8 which is slightly acidic but within physiologic range. In some conditions where the annular portion of the intervertebral disc has degenerated significantly and there appears to be inflamed areas within parts of the annulus, then DMSO ...

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Abstract

An injectable for injection into a spinal disc, and a method to treat a spinal disc with the injectable. The injectable consists essentially of chondroitin sulfate and glucosamine HCl buffered to a pH above about 6.0.

Description

CROSS-REFERENCE TO PRIOR APPLICATION [0001] This application is a continuation-in-part of applicant's co-pending U.S. patent application Ser. No. 10 / 441,130, filed Oct. 4, 2002, which will be abandoned after the filing of this continuation-in-part. In turn Ser No. 10 / 441,130 is a continuation-in-part of applicant's then co-pending application Ser No. 09 / 704,267, filed Oct. 31, 2000 (now abandoned).FIELD OF THE INVENTION [0002] An injectable for, and a method of use to treat spinal discs. BACKGROUND OF THE INVENTION [0003] The human skeleton has evolved to allow for upright posture and bipedal motion. The human spine in its development to support the upright body has developed areas of stress particularly at the base of the neck, the apex of the mid back (thoracic spine) and in the lower back (lower lumbar spine). The spine is formed by bony elements, the vertebrae, and cushions between vertebrae, the intervertebral discs. The spine is then supported by ligaments, fibrous bands of ti...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/00A61K31/7004A61K31/7008A61K31/737A61K47/24A61K47/26A61K47/36A61K47/42
CPCA61K9/0019A61K47/02A61K31/7008A61K31/737A61K47/24A61K47/26A61K47/36A61K47/42A61K31/7004A61K31/726A61K31/445A61K2300/00A61P23/00A61P25/00A61K47/20
Inventor EEK, BJORN C.J.
Owner NOTOGEN INC
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