Methods of food intake management

a food intake and management technology, applied in the field of food intake management, can solve the problems of increasing the risk of illness, increasing the risk of all-cause death, and at least 300,000 excess deaths, and achieving the effect of preventing or reducing weight gain

US20060084686A1Inactive Publication Date: 2006-04-20MOR RES APPL LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
Publication Date
2006-04-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods for regulating food intake in a human subject; for improving a compliance of a human subject to caloric restriction; and for reducing a desire of a human subject to consume fats, utilizing H1-receptor agonists that have a pharmacological half-life that allows an efficient treatment regime thereof are disclosed. The methods can be efficiently used for treating conditions such as overeating, overweight, obesity, binge eating disorder, night eating syndrome, obsessive eating, compulsive eating and bulimia, as well as conditions associated with metabolic derangement such as dyslipidemia.
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Description

RELATED APPLICATIONS

[0001] This application is a Continuation-In-Part (CIP) of PCT Patent Application No. PCT / IL2005 / 000440, filed on Apr. 21, 2005, which claims priority from U.S. Provisional Patent Application No. 60 / 670,290, filed on Apr. 12, 2005, and from Israel Patent Application No. 161595, filed on Apr. 22, 2004. The teachings of the above applications are hereby incorporated by reference as if fully set forth herein.FIELD OF THE INVENTION

[0002] The present invention relates to novel methods for regulating food intake in human subjects and more particularly to methods of preventing or treating conditions in which weight management is beneficial. The present invention further relates to methods of preventing or reducing weight gain associated with drug treatment, smoking cessation and the like. BACKGROUND OF THE INVENTION

[0003] Obesity is a chronic, complex, multi-factorial disease, involving social, cultural, genetic, physiological and psychological components, and is ass...

Examples

example 1

[0282] The following study was conducted to evaluate the effect of oral admisnitration of betahistine on food intake:

[0283] Twenty obese but otherwise healthy persons were recruited. Their characteristics upon recruitment are shown in Table 1. Exclusion criteria for the study were age younger than 18, active diseases, medication use, known hypersensitivity or contra-indication for the use of betahistine.

[0284] Each subject was randomly allocated to receive betahistine 16 mg at 10:00 and 16:00 or placebo. Weight, caloric intake (24 hour recall) and appetite during the day (VAS, Visual Analogue Score) were obtained on day 0, 14 and 28 of the study. Subjects were instructed to eat according to their appetite without limitations.

[0285] Statistical significance was assessed with t-test. BMI stands for body mass index.

TABLE 1Patients' characteristicsTreatmentbetahistinePlaceboAge48 ± 9 38 ± 15NSWeight (kg)93 ± 1790 ± 4 NSBMI35.1 ± 7.3 32.7 ± 1.7 NSMean caloric intake (kcal)975 ± 4721...

example 2

[0301] In a further study, a healthy, overweight woman was treated twice daily with betahistine 16 mg for a month without any dietary changes. The level of certain metabolites of the woman, as observed in blood tests, was measured before and after the betahistine treatment and are presented in Table 2 below.

TABLE 2Day 0Day 30ChangeTotal cholesterol167155−7%HDL-cholesterol5458+7%LDL-cholesterol9984−15% Triglycerides6962−10% Fructoseamine195202+4%

[0302] As seen in Table 2, the results show that during the 30-day time period studied, the total cholesterol level of the subject decreased, with a corresponding decrease in the level of LDL-cholesterol and an increase in the level of HDL-cholesterol. The level of triglycerides decreased, while the level of fructoseamine increased very slightly. It is therefore concluded that the subject restricted her fat intake, (as shown by the decrease in LDL-cholesterol), without reducing her carbohydrate intake, (as shown by the slight increase in fr...