Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for treating hemophilia B

a hemophilia and hemophilia technology, applied in the field of hemophilia b, can solve the problems of ischemic damage to nerves, venous congestion, necrosis of muscles, and hemorrhaging continues in patients with factor ix,

Inactive Publication Date: 2007-01-18
ZYMOGENETICS INC
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This can result in large collections of partially clotted blood putting pressure on adjacent normal tissues and can cause necrosis of muscle, venous congestion, or ischemic damage to nerves.
However, there are times when treating such patients with factor IX produces less than satisfactory results, and hemorrhaging continues.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] The present invention fills this need by administering to patients with hemophilia B factor XIII in conjunction with factor IX, and by administering to patients afflicted with hemophilia B factor XIII in conjunction with factor IX.

[0007] The teachings of all of the references cited herein are incorporated in their entirety by reference.

[0008] Hemophilia B is heterogeneous in both its clinical severity and molecular pathogenesis. Clinical severity roughly correlates with the level of factor IX activity. In severe hemophilia B, the patient will have less than 1% normal factor IX in his plasma (about 0.1 U / ml of plasma). Once a bleeding disorder has been determined to be present, the physician must determine what is the cause of the disorder. For diagnostic purposes, the hemostatic system is divided into two parts: the plasma coagulation factors, and platelets. With the exception of factor XIII deficiency, each of the known defects in coagulation proteins prolongs either the p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Use of factor XIII for treating hemophilia B. A patient having hemophilia B is treated by administering factor XIII, generally in conjunction with factor IX.

Description

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS [0001] This patent application is a continuation of copending and commonly owned U.S. patent application Ser. No. 10 / 416,055, filed May 7, 2003, which is the US national phase of International Patent Application PCT / US01 / 47144, filed Nov. 8, 2001, and claims the benefit of U.S. Provisional Patent Application 60 / 247,362, filed Nov. 10, 2000, each of which being hereby incorporated by reference.BACKGROUND OF THE INVENTION [0002] Hemophilia B is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage due to a defect in the blood coagulation mechanism. Hemophilia B is caused by a deficiency in factor IX. Factor IX is a single-chain, 55,000 Da proenzyme that is converted to an active protease (factor IXa) by factor XIa or by the tissue factor VIIa complex. Factor IXa then activates factor X in conjunction with activated factor VIII. Hemophilia B occurs in 1 in 30,000 male births. Since the disease displ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/37A61K38/45
CPCA61K38/36A61K38/45A61K38/4846A61K2300/00
Inventor OHRSTROM, JANROSE, LYNNBISHOP, PAUL
Owner ZYMOGENETICS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com