Method for treating hemophilia B
a hemophilia and hemophilia technology, applied in the field of hemophilia b, can solve the problems of ischemic damage to nerves, venous congestion, necrosis of muscles, and hemorrhaging continues in patients with factor ix,
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[0006] The present invention fills this need by administering to patients with hemophilia B factor XIII in conjunction with factor IX, and by administering to patients afflicted with hemophilia B factor XIII in conjunction with factor IX.
[0007] The teachings of all of the references cited herein are incorporated in their entirety by reference.
[0008] Hemophilia B is heterogeneous in both its clinical severity and molecular pathogenesis. Clinical severity roughly correlates with the level of factor IX activity. In severe hemophilia B, the patient will have less than 1% normal factor IX in his plasma (about 0.1 U / ml of plasma). Once a bleeding disorder has been determined to be present, the physician must determine what is the cause of the disorder. For diagnostic purposes, the hemostatic system is divided into two parts: the plasma coagulation factors, and platelets. With the exception of factor XIII deficiency, each of the known defects in coagulation proteins prolongs either the p...
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