Methods and probe combinations for detecting melanoma

a technology of melanoma and probe combinations, applied in the field of methods and probe combinations for detecting melanoma, can solve the problems of significant morbidity, no consensus can be reached, and diagnostic ambiguity has significant adverse effects on patients
US20070059747A1Inactive Publication Date: 2007-03-15ABBOTT MOLECULAR INC +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
ABBOTT MOLECULAR INC
Publication Date
2007-03-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This applications claims benefit of U.S. provisional application No. 60 / 713,799, filed Sep. 2, 2005, which is herein incorporated by reference.BACKGROUND OF THE INVENTION

[0002] Melanoma is an important clinical problem. The incidence and mortality of melanoma has been increasing more rapidly than any other malignancy except lung cancer in women. Pathology is the gold standard for establishing the diagnosis of melanoma. Although many cases can be classified reliably with current pathological criteria, there is a significant subset of cases in which no consensus can be reached even among expert pathologists. The effect of the ambiguity on standard clinical practice is illustrated in a recent study from The Netherlands. An expert panel reviewed 1069 consecutive melanocytic lesions that had been submitted for review by clinical pathologists in order to identify the most common diagnostic problems. In 14% (22 / 158) of the cases that had been...

Claims

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