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Recirculating reactor

Inactive Publication Date: 2008-02-21
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]The recirculation system may comprise appropriate piping, tubing etc. for conveying liquid from the chamber outlet to the chamber inlet. It may comprise a pump for recirculating the liquid through the reactor. The pump may be capable of pressurising the liquid prior to the liquid entering the reaction chamber. It may be capable of causing the liquid to pass through the reaction chamber at a sufficient rate as to inhibit, decrease or minimise deactivation of the catalyst by the by-product.

Problems solved by technology

Despite these benefits, there have been few accounts of continuous catalytic systems with immobilized catalysts.
Some catalytic reactions are very difficult to apply to a continuous flow-type system due to reaction inhibition by side-products or gaseous by-products.
In particular, gas-generating catalytic reactions are not well suited to a continuous flow reactor, as the gases give rise to disturbances in and deactivation of the catalysts.
For reactions that produce side-products that inhibit the reaction kinetics, a continuous flow reactor also does not work well, giving rise to lower productivity and catalyst deactivation.

Method used

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Examples

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example 1

[0088]Aza(bisoxazoline) was prepared by the reported method (H. Werner, R. Vicha, A. Gissibl, O. Reiser, J. Org. Chem. 2003, 68, 10166) with moderate yield. It was deprotonated easily with sodium hydride in tetrahydrofuran (THF), and the resulting anion was reacted with electrophilic trialkoxysilane to give T-silylfunctionalized aza(bisoxazoline) [(a) S. S. Lee, J. Y. Ying, “Immobilization of Bisoxazolines onto Siliceous Mesocellular Foams for Asymmetric Cyclopropanation,” 1st International SBE Conference on Bioengineering and Nanotechnology, Singapore, September 2004; b) S. S. Lee, J. Y. Ying, “Immobilization of Bisoxazolines on Siliceous Mesocelluar Foams (MCF) for Asymmetric Cyclopropanation,” 18th North American Catalysis Society Meeting, Cancun, Mexico, June 2003]. Siliceous mesocellular foam (MCF) precapped with trimethylsilyl (TMS) groups was synthesized by adding hexamethyldisilazane (HMDS) (0.4 mmol) to MCF (1.0 g) suspended in toluene, yielding about 0.8 mmol of TMS / g of M...

example 2

[0094]Heterogenized Grubbs-Hoveyda catalyst was derived using MCF-supported Hoveyda ligand, which was immobilized through carbamate linker group (Scheme 3).

[0095]Recirculating reactor: The recirculating reactor used in Example 2 is shown in FIG. 3. With reference to FIG. 3, recirculating reactor 100 comprises reaction chamber 110 and recirculation system 120. Reaction chamber 110 contains MCF-supported catalyst 2. In this example, reaction chamber 110 is a packed bed reactor (column) of length 50 mm and internal diameter 4.6 mm. Catalyst 2 is capable of catalysing reaction of diethyl diallylmalonate (substrate) to form diethyl cyclopent-3-ene-1,1-dicarboxylate (product) and ethylene gas (by-product), as shown in Scheme 4. Reaction chamber 110 comprises chamber body 130, chamber inlet 135 and chamber outlet 140. Recirculation system 120 comprises open container (reservoir) 145, which is capable of functioning as a separator (degasser) by allowing nitrogen to at escape from the liquid...

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Abstract

The invention provides a recirculating reactor for converting a substrate to a product. The reactor comprises a reaction chamber and a recirculation system, said recirculation system comprising a separator. The reaction chamber contains a catalyst, and comprises a chamber body, a chamber inlet and a chamber outlet. The recirculation system is adapted for recirculating liquid from the chamber outlet to the chamber inlet, and the separator is used for separating a by-product from the liquid.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a recirculating reactor and to a method for using the reactor.BACKGROUND OF THE INVENTION[0002]Conventionally, most asymmetric reactions involved batch processing. Flow-type reactors have numerous advantages including more on-stream time, less maintenance, less catalyst attrition and loss, more consistent product streams, and less solvent waste. Despite these benefits, there have been few accounts of continuous catalytic systems with immobilized catalysts. Some catalytic reactions are very difficult to apply to a continuous flow-type system due to reaction inhibition by side-products or gaseous by-products. In particular, gas-generating catalytic reactions are not well suited to a continuous flow reactor, as the gases give rise to disturbances in and deactivation of the catalysts. For reactions that produce side-products that inhibit the reaction kinetics, a continuous flow reactor also does not work well, giving rise to l...

Claims

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Application Information

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IPC IPC(8): B01J8/00
CPCB01J8/0214B01J8/025B01J8/20B01J8/22B01J2219/00905B01J2208/00867B01J2219/00788B01J2219/00835B01J2219/00873B01J19/0093
Inventor YING, JACKIE Y.LEE, SU SEONGLIM, JAEHONGRIDUAN, SITI NURHANNA BINTE
Owner AGENCY FOR SCI TECH & RES