High Temperature Oxidation-Reduction Process to Form Porous Structures on a Medical Implant

a technology of porous structures and high temperature oxidation reduction, applied in the field of biomedical devices, can solve the problems of reducing the effective dose of drugs at the treatment site, significant proportion of restenosed treated vessels, undesirable reactions,

Inactive Publication Date: 2008-08-28
MEDTRONIC VASCULAR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0014]One aspect of the present invention provides a system for treating abnormalities of the cardiovascular system comprising a catheter and a therapeutic agent-carrying stent disposed on the catheter. The stent includes a metallic sten

Problems solved by technology

Soon after the procedure, however, a significant proportion of treated vessels restenose.
Stent insertion may cause undesirable reactions such as inflammation resulting from a foreign body reaction, infection, thrombosis, and proliferation of cell growth that occludes the blood vessel.
The coating is sometimes damaged during expansion of the stent at the delivery site, causing the coating to chip off the stent and release flakes of the polymer coating, which reduces the effective dose of the drug at the t

Method used

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  • High Temperature Oxidation-Reduction Process to Form Porous Structures on a Medical Implant
  • High Temperature Oxidation-Reduction Process to Form Porous Structures on a Medical Implant
  • High Temperature Oxidation-Reduction Process to Form Porous Structures on a Medical Implant

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Embodiment Construction

[0023]Throughout this specification, like numbers refer to like structures.

[0024]The present invention is directed to a system for treating abnormalities of the cardiovascular system comprising a catheter and a therapeutic agent-carrying stent disposed on the catheter. A porous zone is formed at the surface of the stent by exposing a metallic stent framework to a reaction environment in which some metal atoms on the surface of the stent framework are oxidized to a metal oxide and other atoms are reduced to metal carbide or metal sulfide.

[0025]FIG. 2 shows an illustration of a system 200 for treating a vascular condition, comprising therapeutic agent carrying stent 220 coupled to catheter 210, in accordance with one embodiment of the present invention.

[0026]In an exemplary embodiment of the present invention, catheter 210 includes a balloon 212 that expands and deploys therapeutic agent carrying stent 220 within a vessel of the body. After positioning therapeutic agent carrying stent...

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Abstract

A system for treating abnormalities of the cardiovascular system includes a stent having a porous therapeutic agent carrying zone comprising oxidation and reduction products of one or more metals in the stent framework. Another embodiment of the invention includes a method of manufacturing a therapeutic agent carrying stent comprising exposing a metallic stent framework to oxidizing and reducting conditions, and forming a therapeutic agent carrying zone on the surface of the stent framework that includes oxidation and reduction products of one or more metals in the stent framework.

Description

TECHNICAL FIELD[0001]This invention relates generally to biomedical devices that are used for treating vascular conditions. More specifically, the invention relates to a therapeutic agent eluting stent having one or more therapeutic agent eluting structures.BACKGROUND OF THE INVENTION[0002]Stents are generally cylindrical-shaped devices that are radially expandable to hold open a segment of a vessel or other anatomical lumen after implantation into the body lumen.[0003]Various types of stents are in use, including expandable and self-expanding stents. Expandable stents generally are conveyed to the area to be treated on balloon catheters or other expandable devices. For insertion into the body, the stent is positioned in a compressed configuration on the delivery device. For example, the stent may be crimped onto a balloon that is folded or otherwise wrapped about the distal portion of a catheter body that is part of the delivery device. After the stent is positioned across the lesi...

Claims

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Application Information

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IPC IPC(8): A61F2/06
CPCA61L31/022A61L2300/602A61L31/16A61L31/146
Inventor ALLEN, JEFFREYBRIDSALL, MATTHEW
Owner MEDTRONIC VASCULAR INC
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