Pharmaceutical formulations containing lipoic acid derivatives
a technology of lipoic acid and derivatives, which is applied in the direction of anhydride/acid/halide active ingredients, biocide, drug compositions, etc., can solve the problem of no specific guidance regarding the selection of suitable pharmaceutically acceptable carriers
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[0055]Bis-benzyl lipoate was provided in a concentrated form at a concentration of 50 mg / mL dissolved in 1M triethanolamine (TEA). The stability of the drug product was assessed by visual observation and by high-performance liquid chromatography (HPLC) assessment, performed at the beginning and the end of the study. The physical appearance did not change and the purity was found to be >99% pure, both at the beginning and the end of the study. The concentrated bis-benzyl lipoate solution was diluted to an appropriate concentration with 5% dextrose (D5W) to formulate 0.1, 1 and 10 mg / kg doses of bis-benzyl lipoate.
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