Method and Apparatus for Implementing Threshold Based Correction Functions for Biosensors

Abstract

A biosensor system, method and apparatus are provided for implementing threshold based correction functions for biosensors. A primary measurement of an analyte value is obtained. A secondary measurement of a secondary effect is obtained and is compared with a threshold value. A correction function is identified responsive to the compared values. The correction function is applied to the primary measurement of the analyte value to provide a corrected analyte value. The correction method uses correction curves that are provided to correct for an interference effect. The correction curves can be linear or non-linear. The correction method provides different correction functions above and below the threshold value. The correction functions may be dependent or independent of the primary measurement that is being corrected. The correction functions may be either linear or nonlinear.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to Application Nos. 60 / 557,907, filed Mar. 31, 2004 and 60 / 609,570, filed Sep. 13, 2004, which are incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention relates generally to biosensors, and more particularly, relates to a method and apparatus for implementing threshold based correction functions for biosensors.DESCRIPTION OF THE RELATED ART[0003]The quantitative determination of analytes in body fluids is of great importance in the diagnoses and maintenance of certain physiological abnormalities. For example lactate, cholesterol and bilirubin should be monitored in certain individuals. In particular, the determination of glucose in body fluids is of great importance to diabetic individuals who must frequently check the level of glucose in their body fluids as a means of regulating the glucose intake in their diets. While the remainder of the disclosure herein will be d...

AI Technical Summary

Benefits of technology

[0019]In accordance with features of the invention, the secondary measurement of a secondary effect includes a plurality of effects that are use separately or together in combination to identify the correction function. For example, the secondary effects include temperature, Hemoglobin, and the concentration of hematocrit of a blood sample that are identified and used to minimize the interference of the secondary effects on the accuracy of the reported results.

Problems solved by technology

While calorimetric tests can be made semi-quantitative by the use of color charts for comparison of the color change of the redox indicator with the color change obtained using test fluids of known glucose concentration, and can be rendered more highly quantitative by reading the result with a spectrophotometric instrument, the results are generally not as accurate nor are they obtained as quickly as those obtained using an electrochemical biosensor.

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