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Intelligent tissue mimicking ultrasonic phantom and method of preparing the same

a technology of intelligent tissue and ultrasonic phantom, which is applied in the field of biological tissue models, can solve the problems of difficult to evaluate the focusing performance of the hifu treating applicator with a non-standardized biological tissue, undefined, and unfavorable quality control, so as to ensure the consistency of quality and resist deterioration

Inactive Publication Date: 2010-12-30
CHONGQING HAIFU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention solves issues in previous methods for making ultrasonic phantoms by providing one that is smart, easy to prepare, resistant to damage, and can be repeated used. It also allows for precise control over its behavior during use through heat treatment.

Problems solved by technology

The technical problem addressed in this patent text is the lack of an effective and reliable tool for testing the efficacy and safety of new generations of high intensity focused ultrasound (HIFU) systems. Current methods involve use of animal models or simulated materials made up of proteins mixed with other substances like sodium chloride. These tests provide little accurate data about how well the HIFU system works in actual human tissue. There is no established standard for these tests, making them unreliable and expensive. Additionally, current techniques fail to produce reproducible results due to variations in the composition of the materials used to create the simulation tools. To solve these issues, researchers require a more precise and repeatable way to measure the focusing ability of HIFU systems before they can move forward with their development.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

An Intelligent Tissue Mimicking Ultrasonic Phantom Having a Denaturation Temperature, i.e., LCST, of 30° C.

[0061]Ratio of Raw Materials:

Isopropylacrylamide100.0 gInitiating reductant, sodium metabisulfite 0.5 gCrosslinking agent, N, N′-methylene bisacrylamide   1 gInitiating oxidant, ammonium persulfate 0.5 gwater (deionized and degassed water)  898 g

[0062]Steps:

[0063]1) dissolving the isopropylacrylamide monomer in a portion of the water, and mass ratio of the monomer to water is 0.15:1;

[0064]2) adding a crosslinking agent to the solution obtained in step 1), and dissolving the same by stirring;

[0065]3) dissolving the initiating reductant and the initiating oxidant in portions of the water, respectively, the concentrations of the two solutions thus obtained both being 10%;

[0066]4) mixing the aqueous solutions of the isopropylacrylamide monomer, the crosslinking agent, and the initiating reductant uniformly in a container;

[0067]5) packaging the container within a freshness protectio...

example 2

An Intelligent Tissue Mimicking Ultrasonic Phantom Having a Denaturation Temperature, i.e., LCST, of 40° C.

[0072]Ratio of Raw Materials:

Isopropylacrylamide100.0 gDenaturation temperature regulator, acrylamide 3.31 gInitiating reductant, sodium metabisulfite 0.34 gCrosslinking agent, N, N′-methylene bisacrylamide   1 gInitiating oxidant, ammonium persulfate 0.5 gwater (deionized and degassed water)  895 g

[0073]Steps:

[0074]1) dissolving the isopropylacrylamide monomer and acrylamide in a portion of the water, and mass ratio of the monomer to water is 0.15:1;

[0075]2) adding a crosslinking agent to the solution obtained in step 1), and dissolving the same by stirring;

[0076]3) dissolving the initiating reductant and the initiating oxidant in portions of the water, respectively, the concentrations of the two solutions thus obtained both being 1%;

[0077]4) mixing the aqueous solutions of the isopropylacrylamide monomer, the crosslinking agent, and the initiating reductant uniformly in a con...

example 3

An Intelligent Tissue Mimicking Ultrasonic Phantom Having a Denaturation Temperature, i.e., LCST, of 60° C.

[0083]Ratio of Raw Materials:

Isopropylacrylamide100.0 gDenaturation temperature regulator, acrylamide 15.7 gInitiating reductant, sodium metabisulfite 0.4 gCrosslinking agent, N, N′-methylene bisacrylamide 1.2 gInitiating oxidant, ammonium persulfate 0.6 gwater (deionized and degassed water)  882 g

[0084]Steps:

[0085]1) dissolving the isopropylacrylamide monomer and acrylamide in a portion of the water, and mass ratio of the monomer to water is 0.18:1;

[0086]2) adding a crosslinking agent to the solution obtained in step 1), and dissolving the same by stirring;

[0087]3) dissolving the initiating reductant and the initiating oxidant in portions of the water, respectively, the concentrations of the two solutions thus obtained both being 20%;

[0088]4) mixing the aqueous solutions of the isopropylacrylamide monomer, the crosslinking agent, and the initiating reductant uniformly in a con...

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Abstract

An intelligent tissue mimicking ultrasonic phantom, which is a temperature-sensitive polymer gel having the following acoustic properties and other physical characteristics: acoustic velocity: 1500-1550 m/s; acoustic impedance: (1.50−1.60)×106 Pa·s/m; density: 1.01-1.06 g/cm3; and a denaturation temperature, namely, a Lower Critical Solution Temperature (LCST) or a Volume Phase Transition Temperature at which the volume of the phantom changes, adjustable by changing the ratio of raw materials, around which there is a reversible phase transformation between the opaque phase and the transparent phase. Said gel can be a polymer of isopropylacrylamide (NIPA). Said ultrasonic phantom has a transparent appearance, and an adjustable thermal denaturation temperature; the thermal denaturation region of the ultrasonic phantom is distinct and has a well-defined boundary; the material of the phantom is stable and deterioration-resistant, and can ensure the consistency of the quality; the phantom is thermal denaturable with the appearance thereof turning white, while the phantom recovers when the heat is removed, such that it can be used repeatedly.

Description

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Claims

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Application Information

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Owner CHONGQING HAIFU MEDICAL TECH CO LTD
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