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Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans

a technology of burkholderia contaminans and glycopeptides, applied in the field of antifungal compounds, can solve the problems of limitations of current-available antifungal agents regarding their spectra, prevent the direct use of bacteria for fungal disease management, etc., and achieve the effect of reducing or ameliorating the infection

Inactive Publication Date: 2011-06-09
MISSISSIPPI STATE UNIV RES TECH RTC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0008]The present invention provides for novel antifungal cyclic glycopeptide compounds with the name occidiofungin, a novel amino acid attached thereto, and a composition comprising such compounds. The present invention is effective against a broad range of fungal pathogens affecting humans, animals, and plants. Moreover, the present invention disrupts normal fungal membrane morphology. The present invention also provides for a novel bacterial strain that produces the new antifungal compounds.

Problems solved by technology

However, isolation of Burkholderia spp. from cystic fibrosis patients reclassified them as opportunistic pathogens, consequently preventing the direct use of the bacteria for fungal disease management.
Novel antifungals are needed because of the importance of fungal infections in immunocompromised patients, and the limitations of currently-available antifungal agents regarding their spectra of activity and toxicities.

Method used

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  • Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans
  • Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans
  • Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans

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Embodiment Construction

[0026]The novel antifungal cyclic glycopeptide compounds of the present invention are effective against a broad range of fungal infections. The compound structures are disclosed herein, as well as the structure of at least one novel amino acid attached thereto.

[0027]In another embodiment of the present invention, an antifungal composition comprises the novel compound(s) and salts thereof and at least one pharmaceutically or agriculturally acceptable carrier or diluent for administration to human, animal, and / or plant subjects in need of fungicidal therapy and treatment.

[0028]In yet another embodiment, the present invention provides for a new isolated bacterial strain that produces antifungal compounds including the new antifungal compounds described herein.

[0029]For the purposes of this disclosure, abbreviations are as follows: NMR, nuclear magnetic resonance; NOE, nuclear Overhauser effect; NOESY, nuclear Overhauser enhancement spectroscopy; TOCSY, total correlation spectroscopy; C...

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Abstract

The present invention is directed to novel antifungal glycopeptide compounds and salts thereof produced by a strain of Burkholderia contaminans useful for preventing or treating fungal infection or disease in animals and plants and the bacterial strain that produces the compounds.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority from U.S. Provisional Patent Application Ser. No. 61 / 217,026 filed May 26, 2009. The entirety of that provisional application is incorporated herein by reference.STATEMENT OF GOVERNMENT SUPPORT[0002]This invention was made with government support under 0204332 awarded by the Cooperative State Research, Education, and Extension Service, USDA. The government may have certain rights in the invention.FIELD OF THE INVENTION[0003]This invention relates to the field of antifungal compounds and their therapeutic use in the prevention or treatment of fungal infections and diseases. The invention relates to the use of the novel antifungal compounds as pharmaceutical and agricultural fungicides for animals and plants. The invention further relates to the bacterial strain that produces the new antifungal compounds.BACKGROUND OF THE INVENTION[0004]The present invention provides novel antifungal glycopeptides compounds f...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/12C07K7/64A61P31/00C12N1/00A61K38/16
CPCA61K38/12A61P31/10A61K38/16A61K38/17
Inventor LU, SHIENSMITH, JAMES L.AUSTIN, FRANKGU, GANYU
Owner MISSISSIPPI STATE UNIV RES TECH RTC
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