Fucosyllactose as breast milk identical non-digestible oligosaccharide with new functional benefit
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[0041]Nutritional Composition
[0042]Preferably the composition comprising fucosyllactose is a nutritional composition. The composition of the present invention is not human milk. The present composition is preferably enterally administered, more preferably orally.
[0043]The present composition is preferably a nutritional formula, preferably an infant formula. The present composition can be advantageously applied as a complete nutrition for infants. The present composition preferably comprises a lipid component, protein component and carbohydrate component and is preferably administered in liquid form. The present invention includes dry food, preferably a powder, which is accompanied with instructions as to admix said dry food mixture with a suitable liquid, preferably with water.
[0044]The present invention advantageously provides a composition wherein the lipid component provides 5 to 50% of the total calories, the protein component provides 5 to 50% of the total calories, and the dig...
Example
Example 1
[0059]Materials and Methods
[0060]6-8 Weeks old female C57BL / 6 mice (Charles River) received semi-purified AIN-93G-based diets (Research Diet Service, Wijk bij Duurstede, the Netherlands), comprising 1) 2 wt % beta-galacto-oligosaccharide (GOS; source Vivinal GOS, Borculo Domo), fructo-oligosaccharide (FOS; source RaftilineHP, Orafti) and galacturonic acid oligosaccharide (Source AOS) in a 9:1:1.1 ratio. AOS are produced from pectin (Südzucker AG, Mannheim, Germany), with a DP of 1-20. It consists of approximately 75% galacturonic acid oligomers, based on total weight;
[0061]2) 1 wt % lactoneotetraose (LNnT),
[0062]3) 1 wt % 3′-sialyl lactose (3′-SL), or
[0063]4) 1 wt % 2′-fucosyllactose (2′-FL).
[0064]All groups were compared to the unsupplemented control diet. Dietary supplementation started 14 days before the first vaccination and lasted until the end of the experiment, 31 days after the first vaccination.
[0065]Vaccination experiments were performed using Influvac (Solvay Pha...
Example
Example 2
[0074]Infant formula for stimulating NK cell activity comprising per 100 ml (13.9 dry weight):
[0075]1.4 g protein (whey and casein)
[0076]7.3 g digestible carbohydrates (including lactose)
[0077]3.6 g fat (vegetable fat, fish oil)
[0078]0.8 g non-digestible oligosaccharides of which 80 mg 2′-fucosyllactose and 640 mg beta-galacto-oligosaccharides, and 80 mg fructo-oligosaccharides
[0079]Further are included: choline, myo-inositol, taurine, minerals, trace elements, and vitamins as known in the art.
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