Otic formulations, methods and devices

a technology of antifungal and antibacterial, applied in the direction of antibacterial agents, drug compositions, biocides, etc., can solve the problems of reducing affecting the effect of the immune response, and affecting the ability of the immune response to the bacterial infection, so as to reduce the resistance of the bacterial community, reduce the risk of infection, and reduce the effect of complications
US20130178801A1Active Publication Date: 2013-07-11METALCLAD
3 Cites 23 Cited by

Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
METALCLAD
Publication Date
2013-07-11

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Abstract

The present invention relates to a formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, and antifungal, and an anti-inflammatory in a thick, otic carrier. In one embodiment, the formulation comprises a therapeutically effective amount of active ingredients including a fluoroquinolone, a triazole antifungal, a thiocarbamate antifungal, a corticosteroid and a polyene antifungal, as well as a thickener such that the formulation, upon applying to the infected ear canal, gels and remains in the ear canal, continuously releasing the active ingredients for several days, achieving consistent complete (98-100%) clinical resolution of otomycosis and otitis externa in a single application.
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Description

PRIOR RELATED APPLICATIONS

[0001] This application claims priority to 61 / 585,031, filed Jan. 10, 2012, 61 / 625,407, filed Apr. 17, 2012, and 61 / 649,663, filed May 21, 2012, and each incorporated by reference herein in its entirety.FIELD OF THE INVENTION

[0002] The invention relates to an anti-fungal / anti-bacterial / anti-inflammatory formulation for treating ear infection, especially chronic otitis, and methods and devices for delivering the formulation.BACKGROUND OF THE INVENTION

[0003] Ear infections, especially fungal ear infections, are common ear disorders often occurring in warm and humid climates. Fungal otitis externa is a fungal infection of the external auditory canal and associated complications. It has been reported that as high as 30.4% of otitis externa patients exhibit symptoms of fungal otitis or inflammatory conditions of the ear.

[0004] Common symptoms of ear fungal infection include otalgia, otorrhea, hearing loss, aural fullness, pruritus and tinnitus. Several factors that ...

Claims

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