90results about How to "Continuous release" patented technology

The present invention relates to biocompatible polymeric beads and to biocompatible delivery systems comprising same for controlled or sustained release of bioactive molecules. In particular, the invention relates to polymeric beads having a two-phase core and shell structure and to polymeric delivery systems comprising same that provide sustained release of the bioactive compound.

The present invention relates to a foam dispenser (1) having a pump assembly (2), comprising a liquid pumps (5), an air pump (6) and a common actuation part (7) to simultaneously actuate said liquid pump (5) and said air pump (6), wherein said pump assembly (2) comprises a dispensing channel (15) having a dispensing opening (17). The pump assembly (2) further comprises a porous matrix (18) which contains a dispensate material, a contact surface (19) of said porous matrix (18) being arranged in communication with said dispensing channel (15), so that foam being formed in said pump assembly (2) and dispensed through said dispensing channel (15) comes into contact with said contact surface (19) to introduce dispensate material released from said porous matrix (18) in said foam.

The present invention relates to a formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, and antifungal, and an anti-inflammatory in a thick, otic carrier. In one embodiment, the formulation comprises a therapeutically effective amount of active ingredients including a fluoroquinolone, a triazole antifungal, a thiocarbamate antifungal, a corticosteroid and a polyene antifungal, as well as a thickener such that the formulation, upon applying to the infected ear canal, gels and remains in the ear canal, continuously releasing the active ingredients for several days, achieving consistent complete (98-100%) clinical resolution of otomycosis and otitis externa in a single application.

The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic acid, as selective estrogen receptor modulators. Also provided are methods for the treatment and/or prevention of estrogen stimulated diseases in mammals including breast, uterine, ovarian, prostrate and colon cancer, osteoporosis, cardiovascular disease, and benign proliferative disorders, as well as pharmaceutical compositions of the compounds of the present invention.

The present invention provides a biocompatible coating comprising calcium phosphate that is functionally graded across the thickness of the coating. The coating, which preferably includes hydroxyapatite, is particularly useful for coating implants, such as dental or orthopedic implants. The functionally graded coating is generally crystalline near the interface with the surface of the implant, with crystallinity and crystal diameter decreasing toward the outer layer of the coating. The invention further provides methods for preparing a coated implant comprising a functionally graded calcium phosphate coating thereon. Furthermore, an antimicrobial agent can be dispersed within the calcium phosphate coating at discrete locations to provide for a coating with tailored release of the antimicrobial agent.

The invention provides a three continuous furnace technology for continuous production of anode copper with copper concentrate. The technology is particularly characterized in that a smelting furnace, a copper making furnace and an anode furnace are in tandem arrangement successively, and kilns are connected by chutes. The technology comprises the steps that the copper concentrate and flux enter the smelting furnace and react with oxygen-enriched air to generate white matte, smelting slag and high-temperature smoke; the smelting slag overflows continuously; a slow cooling slag ladle is put through the chutes for floatation and depletion; the white matte continuously flows into the copper making furnace via siphon through the chute and reacts with the flux and the oxygen-enriched air to generate raw copper, copper converting slag and high-temperature smoke; the raw copper continuously or intermittently flows into the anode furnace via siphon through the chute; the anode furnace alternately operates and produces the anode copper via oxygenation and reduction; and the converting slag is regularly discharged, chilled, broken and returned to the smelting furnace. The technology achieves continuous operation of smelting production of the raw copper with the copper concentrate.

The present invention relates to the use of a resorcinol derivative, i.e., 4-(2,4-dihydroxyphenyl)cyclohexanol, or a pharmaceutically acceptable salt thereof, as a skin lightening agent.

The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.

Provided is a matrix type antimicrobial vehicle, including: a matrix layer comprising an antimicrobial agent and an adhesive; an antimicrobial agent-releasing layer formed on one surface of the matrix layer; and a release liner formed on the other surface of the matrix layer, and a method for preparing the same. The matrix type antimicrobial vehicle is incorporated into a package having a medical kit so that the antimicrobial agent is released to the surface of medical kit or package continuously. Therefore, it is possible for the surface of the medical kit or package to maintain a constant concentration of antimicrobial agent continuously even when the medical kit or package is stored for a long time.

The invention relates to a ventilation and explosion suppression device for a seal ring of a floating roof tank. The ventilation and explosion suppression device comprises an air supply branch pipe which is communicated with the floating roof tank and externally connected with a gas transmission mother pipe, the annular seal ring is arranged between the tank wall of an oil tank and the side wall of a floating roof, the annular seal ring comprises a primary sealing piece and a secondary sealing piece, and the ventilation and explosion suppression device is characterized in that the ventilation and explosion suppression device further comprises a central distributor, a plurality of radial branch gas pipes and a plurality of arc-shaped gas distribution pipes, wherein the central distributor is arranged in the center position above a top plate of the floating roof and communicated with the air supply branch pipe; the plurality of the radial branch gas pipes are arranged between the central distributor and the seal ring and communicated with the central distributor; the plurality of the arc-shaped gas distribution pipes are arranged in the seal ring or an edge floating cabin and communicated with the radial branch gas pipes, and a plurality of exhaust holes or gas jet heads for conveying gas into the seal ring are arranged on the arc-shaped gas distribution pipes; and a gap for exhausting tail gas is arranged between the tank wall and the top end of the seal ring. The whole set of the system has the advantages of simple structure, low cost, and convenience in use and maintenance, thereby being a simple, economic, reasonable, effective and ideal technological way for realizing intrinsic safety of the oil tank.

The invention discloses a microwave chemical method of ethane, which is characterized by the following: dehydrating alcohol into ethane irradiated by microwave at 120-300 deg.c and 300MHz-300GHz frequency; adopting catalyst with molecular formulation at Hn+2PnO3n+1 (n is positive integral phosphoric acid, pyrophosphoric acid, polyphosphoric acids or their carbethoxy).

Provided is a sustained-release formulation: (a) a sustained-release core including an active ingredient and a polymer having erosion and swelling property in mammalian intestinal secretions, (b) an enteric film coating layer coated on the sustained-release core, and (c) an active ingredient-containing film coating layer coated on the enteric film coating layer and including the active ingredient and hydrophilic polymer for film coating.